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1. WO2009155551 - TRIAZOLOPYRIDINE JAK INHIBITOR COMPOUNDS AND METHODS

Publication Number WO/2009/155551
Publication Date 23.12.2009
International Application No. PCT/US2009/048017
International Filing Date 19.06.2009
IPC
A01N 43/64 2006.1
AHUMAN NECESSITIES
01AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
NPRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
43Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
64having rings with three nitrogen atoms as the only ring hetero atoms
A61K 31/41 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
395having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
41having five-membered rings with two or more ring hetero atoms, at least one of which is nitrogen, e.g. tetrazole
CPC
A61K 31/437
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
395having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
435having six-membered rings with one nitrogen as the only ring hetero atom
4353ortho- or peri-condensed with heterocyclic ring systems
437the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
A61K 31/496
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
395having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
495having six-membered rings with two ; or more; nitrogen atoms as the only ring heteroatoms, e.g. piperazine ; or tetrazines
496Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene
A61K 31/5377
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
395having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
535having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
53751,4-Oxazines, e.g. morpholine
5377not condensed and containing further heterocyclic rings, e.g. timolol
A61P 1/16
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
1Drugs for disorders of the alimentary tract or the digestive system
16for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
A61P 17/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
17Drugs for dermatological disorders
A61P 17/04
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
17Drugs for dermatological disorders
04Antipruritics
Applicants
  • GENENTECH, INC. [US]/[US] (AllExceptUS)
  • ZHU, Bing-Yan [US]/[US] (UsOnly)
  • SIU, Michael [US]/[US] (UsOnly)
  • MAGNUSON, Steven, R. [CA]/[US] (UsOnly)
  • PASTOR, Richard [US]/[US] (UsOnly)
  • HAIYING, He [CN]/[CN] (UsOnly)
  • YISONG, Xiao [CN]/[CN] (UsOnly)
  • JIFU, Zheng [CN]/[CN] (UsOnly)
  • XING, Xu [CN]/[CN] (UsOnly)
  • JUNPING, Zhao [CN]/[CN] (UsOnly)
  • Joseph P. LYSSIKATOS [US]/[US] (UsOnly)
  • HURLEY, Christopher A. [GB]/[GB] (UsOnly)
  • LIU, Wendy [CN]/[US] (UsOnly)
  • LIANG, Jun [CN]/[US] (UsOnly)
Inventors
  • ZHU, Bing-Yan
  • SIU, Michael
  • MAGNUSON, Steven, R.
  • PASTOR, Richard
  • HAIYING, He
  • YISONG, Xiao
  • JIFU, Zheng
  • XING, Xu
  • JUNPING, Zhao
  • Joseph P. LYSSIKATOS
  • HURLEY, Christopher A.
  • LIU, Wendy
  • LIANG, Jun
Priority Data
61/074,50620.06.2008US
Publication Language English (en)
Filing Language English (EN)
Designated States
Title
(EN) TRIAZOLOPYRIDINE JAK INHIBITOR COMPOUNDS AND METHODS
(FR) COMPOSÉS TRIAZOLOPYRIDINE INHIBITEURS DE JAK KINASE ET PROCÉDÉS
Abstract
(EN) A compound of Formula (I), enantiomers, diasteriomers, tautomers or pharmaceutically acceptable salts thereof, wherein R1, R2, R3, R4 and R5 are defined herein, are useful as JAK kinase inhibitors. A pharmaceutical composition that includes a compound of Formula (I) and a pharmaceutically acceptable carrier, adjuvant or vehicle, and methods of treating or lessening the severity of a disease or condition responsive to the inhibition of JAK kinase activity in a patient are disclosed. Formula (I).
(FR) Composé de formule (I), y compris ses énantiomères, diastériomères, tautomères ou sels pharmaceutiquement acceptables correspondants, sachant que R1, R2, R3, R4 et R5 sont tels que définis selon l'invention, ce composé étant utile comme inhibiteur de JAK kinase. On décrit une composition pharmaceutique comprenant un tel composé et un vecteur, adjuvant ou véhicule pharmaceutiquement acceptable, et des procédés de traitement ou d'atténuation de la sévérité d'une maladie ou d'une affection en réaction à l'inhibition de l'activité JAK kinase chez un patient.
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