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1. (WO2009155551) TRIAZOLOPYRIDINE JAK INHIBITOR COMPOUNDS AND METHODS
Latest bibliographic data on file with the International Bureau   

Pub. No.: WO/2009/155551 International Application No.: PCT/US2009/048017
Publication Date: 23.12.2009 International Filing Date: 19.06.2009
IPC:
A01N 43/64 (2006.01) ,A61K 31/41 (2006.01)
A HUMAN NECESSITIES
01
AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
N
PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
43
Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
64
having rings with three nitrogen atoms as the only ring hetero atoms
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
395
having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
41
having five-membered rings with two or more ring hetero atoms, at least one of which is nitrogen, e.g. tetrazole
Applicants:
ZHU, Bing-Yan [US/US]; US (UsOnly)
SIU, Michael [US/US]; US (UsOnly)
MAGNUSON, Steven, R. [CA/US]; US (UsOnly)
PASTOR, Richard [US/US]; US (UsOnly)
HAIYING, He [CN/CN]; CN (UsOnly)
YISONG, Xiao [CN/CN]; CN (UsOnly)
JIFU, Zheng [CN/CN]; CN (UsOnly)
XING, Xu [CN/CN]; CN (UsOnly)
JUNPING, Zhao [CN/CN]; CN (UsOnly)
Joseph P. LYSSIKATOS [US/US]; US (UsOnly)
HURLEY, Christopher A. [GB/GB]; GB (UsOnly)
LIU, Wendy [CN/US]; US (UsOnly)
LIANG, Jun [CN/US]; US (UsOnly)
GENENTECH, INC. [US/US]; 1 DNA Way South San Francisco, CA 94080-4990, US (AllExceptUS)
Inventors:
ZHU, Bing-Yan; US
SIU, Michael; US
MAGNUSON, Steven, R.; US
PASTOR, Richard; US
HAIYING, He; CN
YISONG, Xiao; CN
JIFU, Zheng; CN
XING, Xu; CN
JUNPING, Zhao; CN
Joseph P. LYSSIKATOS; US
HURLEY, Christopher A.; GB
LIU, Wendy; US
LIANG, Jun; US
Priority Data:
61/074,50620.06.2008US
Title (EN) TRIAZOLOPYRIDINE JAK INHIBITOR COMPOUNDS AND METHODS
(FR) COMPOSÉS TRIAZOLOPYRIDINE INHIBITEURS DE JAK KINASE ET PROCÉDÉS
Abstract:
(EN) A compound of Formula (I), enantiomers, diasteriomers, tautomers or pharmaceutically acceptable salts thereof, wherein R1, R2, R3, R4 and R5 are defined herein, are useful as JAK kinase inhibitors. A pharmaceutical composition that includes a compound of Formula (I) and a pharmaceutically acceptable carrier, adjuvant or vehicle, and methods of treating or lessening the severity of a disease or condition responsive to the inhibition of JAK kinase activity in a patient are disclosed. Formula (I).
(FR) Composé de formule (I), y compris ses énantiomères, diastériomères, tautomères ou sels pharmaceutiquement acceptables correspondants, sachant que R1, R2, R3, R4 et R5 sont tels que définis selon l'invention, ce composé étant utile comme inhibiteur de JAK kinase. On décrit une composition pharmaceutique comprenant un tel composé et un vecteur, adjuvant ou véhicule pharmaceutiquement acceptable, et des procédés de traitement ou d'atténuation de la sévérité d'une maladie ou d'une affection en réaction à l'inhibition de l'activité JAK kinase chez un patient.
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Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PE, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (EPO) (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)