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1. WO2009151599 - SUBSTITUTED PYRROLES AND METHODS OF USE

Publication Number WO/2009/151599
Publication Date 17.12.2009
International Application No. PCT/US2009/003493
International Filing Date 10.06.2009
IPC
C07D 401/12 2006.1
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
401Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
02containing two hetero rings
12linked by a chain containing hetero atoms as chain links
A61K 31/4439 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
395having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
435having six-membered rings with one nitrogen as the only ring hetero atom
44Non-condensed pyridines; Hydrogenated derivatives thereof
4427containing further heterocyclic ring systems
4439containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
A61P 35/00 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
35Antineoplastic agents
CPC
A61P 35/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
35Antineoplastic agents
A61P 35/02
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
35Antineoplastic agents
02specific for leukemia
C07D 401/12
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
401Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
02containing two hetero rings
12linked by a chain containing hetero atoms as chain links
Applicants
  • GENENTECH, INC. [US]/[US] (AllExceptUS)
  • GAZZARD, Lewis, J. [GB]/[US] (UsOnly)
  • LYSSIKATOS, Joseph, P. [US]/[US] (UsOnly)
Inventors
  • GAZZARD, Lewis, J.
  • LYSSIKATOS, Joseph, P.
Agents
  • WANG, Min
Priority Data
61/060,75211.06.2008US
61/104,61810.10.2008US
Publication Language English (en)
Filing Language English (EN)
Designated States
Title
(EN) SUBSTITUTED PYRROLES AND METHODS OF USE
(FR) PYRROLES SUBSTITUÉS ET LEURS PROCÉDÉS D'UTILISATION
Abstract
(EN) The invention relates to substituted pyrrole compounds of Formula (I) which are useful as kinase inhibitors, more specifically useful as checkpoint kinase 1 (chkl) inhibitors, thus useful as cancer therapeutics. The invention also relates to compositions, more specifically pharmaceutical compositions comprising these compounds and methods of using the same to treat various forms of cancer and hyperproliferative disorders, as well as methods of using the compounds for in vitro, in situ, and in vivo diagnosis or treatment of mammalian cells, or associated pathological conditions.
(FR) L'invention porte sur des composés pyrroles substitués de Formule (I) qui sont utiles en tant qu'inhibiteurs de kinases, plus spécifiquement utiles en tant qu'inhibiteurs de la checkpoint kinase 1 (chkl), étant de ce fait utiles en tant que produits thérapeutiques contre le cancer. L'invention porte également sur des compositions, plus spécifiquement sur des compositions pharmaceutiques comprenant ces composés, et sur des procédés d'utilisation de celles-ci pour traiter diverses formes de cancer et des troubles hyperprolifératifs, ainsi que sur des procédés d'utilisation des composés pour un diagnostic ou un traitement in vitro, in situ et in vivo de cellules de mammifère ou d'états pathologiques associés.
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