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1. (WO2009143526) METHODS OF TREATMENT UTILIZING BINDING PROTEINS OF THE INTERLEUKIN-21 RECEPTOR
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2009/143526    International Application No.:    PCT/US2009/045188
Publication Date: 26.11.2009 International Filing Date: 26.05.2009
IPC:
A61K 38/17 (2006.01), A61K 38/20 (2006.01), C07K 14/715 (2006.01), C07K 16/28 (2006.01)
Applicants: WYETH LLC [US/US]; Five Giralda Farms Madison, NJ 07940 (US) (For All Designated States Except US).
BLOOM, Laird [US/US]; (US) (For US Only).
GILL, Davinder [US/US]; (US) (For US Only).
VUGMEYSTER, Yulia [US/US]; (US) (For US Only).
YOUNG, Deborah, A. [US/US]; (US) (For US Only).
O'TOOLE, Margot [US/US]; (US) (For US Only).
GUAY, Heath, M. [US/US]; (US) (For US Only).
ADKINS, Karissa, K. [US/US]; (US) (For US Only).
WEAVER, Amy, Arlene [US/US]; (US) (For US Only).
JAIN, Sadhana [US/US]; (US) (For US Only).
ARAI, Maya [US/US]; (US) (For US Only)
Inventors: BLOOM, Laird; (US).
GILL, Davinder; (US).
VUGMEYSTER, Yulia; (US).
YOUNG, Deborah, A.; (US).
O'TOOLE, Margot; (US).
GUAY, Heath, M.; (US).
ADKINS, Karissa, K.; (US).
WEAVER, Amy, Arlene; (US).
JAIN, Sadhana; (US).
ARAI, Maya; (US)
Agent: MOLENDA, Victoria, S.; Fitzpatrick, Cella, Harper & Scinto 1290 Avenue of the Americas New York, NY 10104-3800 (US)
Priority Data:
61/055,543 23.05.2008 US
61/099,476 23.09.2008 US
Title (EN) METHODS OF TREATMENT UTILIZING BINDING PROTEINS OF THE INTERLEUKIN-21 RECEPTOR
(FR) PROCÉDÉS DE TRAITEMENT UTILISANT DES PROTÉINES DE LIAISON DU RÉCEPTEUR D'INTERLEUKINE-21
Abstract: front page image
(EN)The present invention provides binding proteins and antigen-binding fragments thereof, including human antibodies, that specifically bind to the human interleukin-21 receptor (IL-21R), and methods of using them. The binding proteins can act as, e.g., antagonists of IL-21R activity, thereby modulating immune responses in general, and those mediated by IL-21R in particular. The disclosed compositions and methods may be used, e.g., in diagnosing, treating, and/or preventing IL-21R- associated disorders, e.g., inflammatory disorders, autoimmune diseases, allergies, transplant rejection, and other immune system disorders.
(FR)L'invention concerne des protéines de liaison et des fragments de liaison à un antigène de celles-ci, y compris des anticorps humains, qui se lient spécifiquement au récepteur d'interleukine-21 humain (IL-21R) et des procédés pour les utiliser. Les protéines de liaison peuvent agir, par exemple, comme des antagonistes de l'activité d'IL-21R, modulant ainsi les réponses immunitaires en général, et celles véhiculées par IL-21R en particulier. Les compositions et procédés divulgués peuvent être utilisés, par exemple, dans le diagnostic, le traitement et/ou la prévention de troubles associés à IL-21R, par exemple des troubles inflammatoires, des maladies auto-immunitaires, des allergies, le rejet de greffe ou d'autres troubles du système immunitaire.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)