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1. (WO2009143369) METHOD OF PREPARING NUCLEOSIDES AND ANALOGS THEREOF WITHOUT USING CHROMATOGRAPHY
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2009/143369    International Application No.:    PCT/US2009/044887
Publication Date: 26.11.2009 International Filing Date: 21.05.2009
IPC:
C07H 1/06 (2006.01), C07H 11/04 (2006.01), C07H 19/10 (2006.01), C07H 19/20 (2006.01)
Applicants: ISIS PHARMACEUTICALS, INC. [US/US]; 1896 Rutherford Road Carlsbad, CA 92008 (US) (For All Designated States Except US).
VASQUEZ, Gillermo [US/US]; (US) (For US Only)
Inventors: VASQUEZ, Gillermo; (US)
Agent: HARRELSON, John, A.; Woodcock Washburn, LLP Cira Centre, 12th Floor 2929 Arch Street Philadelphia, PA 19104-2891 (US)
Priority Data:
61/055,257 22.05.2008 US
Title (EN) METHOD OF PREPARING NUCLEOSIDES AND ANALOGS THEREOF WITHOUT USING CHROMATOGRAPHY
(FR) PROCÉDÉ DE PRÉPARATION DE NUCLÉOSIDES ET DE LEURS ANALOGUES SANS UTILISER DE CHROMATOGRAPHIE
Abstract: front page image
(EN)Provided herein are methods for preparing purified modified nucleosides from reaction mixtures using precipitation as opposed to traditional chromatographic methods. The methods are particularly amenable to protected nucleosides and nucleoside phosphoramidites wherein the nucleosides can be modified.
(FR)L’invention concerne des procédés de préparation de nucléosides modifiés et purifiés provenant de mélanges de réaction utilisant une précipitation par opposition aux procédés chromatographiques traditionnels. Les procédés sont particulièrement indiqués pour des nucléosides protégés et des phosphoramidites de nucléosides, les nucléosides pouvant être modifiés.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)