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1. (WO2009143292) METHOD OF TREATING PNEUMOCONIOSIS WITH OLIGODEOXYNUCLEOTIDES
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2009/143292    International Application No.:    PCT/US2009/044739
Publication Date: 26.11.2009 International Filing Date: 20.05.2009
IPC:
A61K 31/7088 (2006.01), A61P 11/00 (2006.01), A61P 29/00 (2006.01)
Applicants: THE GOVERNMENT OF THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY OF THE DEPARTMENT OF HEALTH AND HUMAN SERVICES [US/US]; National Institutes Of Health Office Of Technology Transfer 6011 Executive Blvd., Suite 325 MSC 7660 Bethesda, MD 20897-7660 (US) (For All Designated States Except US).
KLINMAN, Dennis, M. [US/US]; (US) (For US Only).
SATO, Takashi [JP/JP]; (JP) (For US Only)
Inventors: KLINMAN, Dennis, M.; (US).
SATO, Takashi; (JP)
Agent: SIEGEL, Susan, Alpert; (US)
Priority Data:
61/055,102 21.05.2008 US
Title (EN) METHOD OF TREATING PNEUMOCONIOSIS WITH OLIGODEOXYNUCLEOTIDES
(FR) PROCÉDÉ DE TRAITEMENT D'UNE PNEUMOCONIOSE PAR DES OLIGODÉSOXYNUCLÉOTIDES
Abstract: front page image
(EN)Methods are disclosed for treating, preventing or reducing the risk of developing occupational lung diseases, such as pneumoconiosis. In several embodiments, the methods include administering a therapeutically effective amount of the suppressive ODN to a subject having or at risk of developing a pneumoconiosis, thereby treating or inhibiting the pneumoconiosis. In several examples, thee subject can have or be at risk of developing silicosis, asbestosis or berryliosis. The method can include selecting a subject exposed to, or at risk of exposure to, inorganic particles, including, but not limited to silica, asbestos, berrylium, coal dust, or bauxite.
(FR)L'invention porte sur des procédés pour traiter, prévenir ou réduire le risque de développer des maladies pulmonaires professionnelles, telles que la pneumoconiose. Dans plusieurs modes de réalisation, les procédés comprennent l'administration d'une quantité thérapeutiquement efficace de l'oligodésoxynucléotide (ODN) suppresseur à un sujet ayant ou à risque de développer une pneumoconiose, permettant ainsi de traiter ou d'inhiber la pneumoconiose. Dans plusieurs exemples, ce sujet peut avoir ou être à risque de développer une silicose, une amiantose ou une berryliose. Le procédé peut comprendre la sélection d'un sujet exposé à, ou à risque d'une exposition à, des particules inorganiques, comprenant, mais sans y être limitées, la silice, l'amiante, le béryllium, la poussière de charbon ou la bauxite.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)