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Machine translation
1. (WO2009143168) VACCINE ASSAYS
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2009/143168    International Application No.:    PCT/US2009/044539
Publication Date: 26.11.2009 International Filing Date: 19.05.2009
IPC:
G01N 33/53 (2006.01), G01N 33/569 (2006.01), A61K 39/00 (2006.01), A61K 39/095 (2006.01)
Applicants: NOVARTIS AG [CH/CH]; Lichstrasse 35, Bldg. 200-322 CH-4002 Basel (CH) (For All Designated States Except US).
DONNELLY, John [US/IT]; (US) (For US Only).
WU, Ping [US/US]; (US) (For US Only).
SANTOS, George [US/US]; (US) (For US Only).
GIULIANI, Marzia, Monica [IT/IT]; (US) (For US Only).
ANDREWS, William [US/US]; (US) (For US Only).
CHEN, Jie [CN/US]; (US) (For US Only)
Inventors: DONNELLY, John; (US).
WU, Ping; (US).
SANTOS, George; (US).
GIULIANI, Marzia, Monica; (US).
ANDREWS, William; (US).
CHEN, Jie; (US)
Agent: NOVARTIS VACCINES AND DIAGNOSTICS, INC; Intellectual Property - X100B P.O. Box 8097 Emeryville, California 94662-8097 (US)
Priority Data:
61/054,439 19.05.2008 US
Title (EN) VACCINE ASSAYS
(FR) ESSAIS DE VACCIN
Abstract: front page image
(EN)The present invention is directed to methods, assays and compositions for implementing such methods and assays for assessing efficacy of individual components in multi-component vaccines and for assessing efficacy of a vaccine against a pathogen. In one aspect, the method of assessing efficacy of a vaccine against a pathogen is a quick assay that tests for an activity correlated with efficacy such as binding in an ELISA rather than requiring the time and expense of an assay that detects actual bactericidal activity. In another aspect, the method for testing the efficacy of an individual component in a multi-component vaccine includes obtaining an immune sample from a subject inoculated with the multi-component vaccine; blocking the portion of the immune sample that recognizes the individual component such as by addition of the individual component, and testing the efficacy of the immune sample to respond to the pathogen.
(FR)La présente invention porte sur des procédés, des essais et des compositions pour mettre en œuvre de tels procédés et de tels essais afin d'évaluer l'efficacité de composants individuels dans des vaccins à multiples composants et d'évaluer le rendement d'un vaccin contre un pathogène. Sous un aspect, le procédé d'évaluation de l'efficacité d'un vaccin contre un pathogène est un essai rapide qui teste une activité corrélée à l'efficacité telle que la liaison dans un test ELISA plutôt que de nécessiter le temps et la dépense d'un essai qui détecte l'activité bactéricide réelle. Sous un autre aspect, le procédé pour tester l'efficacité d'un composant individuel dans un vaccin à multiples composants comprend l'obtention d'un échantillon immun à partir d'un sujet auquel on a inoculé le vaccin à multiples composants; le blocage de la partie de l'échantillon immun qui reconnaît le composant individuel, par exemple par addition du composant individuel, et le test de l'efficacité de l'échantillon immun pour répondre au pathogène.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)