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1. (WO2009143041) EFFICIENT PRODUCTION OF HETEROLOGOUS PROTEINS USING MANNOSYL TRANSFERASE INHIBITORS
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2009/143041    International Application No.:    PCT/US2009/044297
Publication Date: 26.11.2009 International Filing Date: 18.05.2009
IPC:
C07D 277/36 (2006.01), C12P 21/02 (2006.01)
Applicants: MERCK SHARP & DOHME CORP. [US/US]; 126 East Lincoln Avenue Rahway, NJ 07065-0907 (US) (For All Designated States Except US).
DESAI, Ranjit [US/US]; (US) (For US Only).
YANG, Lihu [US/US]; (US) (For US Only)
Inventors: DESAI, Ranjit; (US).
YANG, Lihu; (US)
Common
Representative:
MERCK SHARP & DOHME CORP.; 126 East Lincoln Avenue Rahway, NJ 07065-0907 (US)
Priority Data:
61/128,251 20.05.2008 US
Title (EN) EFFICIENT PRODUCTION OF HETEROLOGOUS PROTEINS USING MANNOSYL TRANSFERASE INHIBITORS
(FR) PRODUCTION EFFICACE DE PROTÉINES HÉTÉROLOGUES À L'AIDE D'INHIBITEURS DE LA MANNOSYL TRANSFÉRASE
Abstract: front page image
(EN)Compounds and methods are described for producing protein compositions having reduced amounts of O-linked glycosylation. The method includes producing the protein in cells cultured in the presence of certain benzylidene thiazolidinediones inhibitors of Pmt-mediated O-linked glycosylation.
(FR)L'invention porte sur des composés et sur des procédés de production de compositions de protéine renfermant des quantités réduites de glycosylation à liaison O. Le procédé consiste à produire de la protéine dans des cellules cultivées en présence de certains inhibiteurs de benzylidène thiazolidinediones de glycosylation à liaison O à médiation par Pmt.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)