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1. (WO2009142822) 2-F MODIFIED RNA INTERFERENCE AGENTS
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2009/142822    International Application No.:    PCT/US2009/038433
Publication Date: 26.11.2009 International Filing Date: 26.03.2009
IPC:
C12N 15/11 (2006.01), A61K 31/712 (2006.01), A61K 31/7125 (2006.01), A61K 31/713 (2006.01), C07H 19/073 (2006.01), C07H 19/23 (2006.01), C07H 21/04 (2006.01), C07H 19/173 (2006.01)
Applicants: ALNYLAM PHARMACEUTICALS, INC. [US/US]; 300 Third Street Cambridge, MA 02142 (US) (For All Designated States Except US).
MANOHARAN, Muthiah [US/US]; (US) (For US Only).
RAJEEV, Kallanthottathil, G. [IN/US]; (US) (For US Only)
Inventors: MANOHARAN, Muthiah; (US).
RAJEEV, Kallanthottathil, G.; (US)
Agent: TOWNES, Jeffrey, N.; (US)
Priority Data:
61/105,307 14.10.2008 US
61/039,574 26.03.2008 US
61/040,414 28.03.2008 US
Title (EN) 2-F MODIFIED RNA INTERFERENCE AGENTS
(FR) AGENTS D'INTERFÉRENCE ARN À MODIFICATION 2-F
Abstract: front page image
(EN)This invention relates to a method of modulating the expression of a target gene in an organism comprising administering an iRNA agent, wherein the iRNA comprises at least one 2'-deoxy-2'-fluoro (2'-F) nucleotide in the antisense strand and at least one modified nucleotide in the sense strand. The invention also relates to compositions comprising a single-stranded oligonucleotide that contains at least one 2'-deoxy-2'-fluoro (2'-F) nucleotide. siRNA molecule containing these oligonucleotides have decreased immunogenicity.
(FR)La présente invention concerne un procédé de modulation de l'expression d'un gène cible dans un organisme comprenant l'administration d'un agent iARN, l'iARN comprenant au moins un nucléotide 2'-désoxy-2'-fluoro (2'-F) dans le brin antisens et au moins un nucléotide modifié dans le brin sens. L'invention concerne également des compositions comprenant un oligonucléotide simple brin contenant au moins un nucléotide 2'-désoxy-2'-fluoro (2'-F). Une molécule de siARN contenant ces oligonucléotides présente une immunogénicité réduite.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)