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1. (WO2009142744) PREDICTING HEMOSTATIC RISK; DEPENDENCE ON PLASMA COMPOSITION
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2009/142744    International Application No.:    PCT/US2009/003148
Publication Date: 26.11.2009 International Filing Date: 20.05.2009
IPC:
C12Q 1/56 (2006.01), G01N 33/50 (2006.01)
Applicants: THE UNIVERSITY OF VERMONT AND STATE AGRICULTURE COLLEGE [US/US]; College of Medicine E109 Health Science Complex 340 Waterman Bldg. Burlington, VT 05405 (US) (For All Designated States Except US).
MANN, Kenneth, G. [US/US]; (US) (For US Only).
ZIEDINS, Kathleen, Brummel [US/US]; (US) (For US Only).
ORFEO, Thomas [US/US]; (US) (For US Only).
HOCKIN, Matthew, F. [US/US]; (US) (For US Only).
EVERSE, Stephen, J. [US/US]; (US) (For US Only)
Inventors: MANN, Kenneth, G.; (US).
ZIEDINS, Kathleen, Brummel; (US).
ORFEO, Thomas; (US).
HOCKIN, Matthew, F.; (US).
EVERSE, Stephen, J.; (US)
Agent: CONLIN, David, G.; (US)
Priority Data:
61/054,503 20.05.2008 US
Title (EN) PREDICTING HEMOSTATIC RISK; DEPENDENCE ON PLASMA COMPOSITION
(FR) PRÉDICTION DU RISQUE HÉMOSTATIQUE EN FONCTION DE LA COMPOSITION DU PLASMA
Abstract: front page image
(EN)Featured are methods for assessing hemostatic risk including the risk for ACS. Such methods include acquiring blood/plasma composition based on a biological sample obtained from a subject, determining parameters associated with blood clotting, simulating in silico blood clotting using the determined parameters and comparing the results of such simulation to a reference and to determine the hemostatic risk from said comparing. In further embodiments, such methods further include selecting a treatment regime or protocol based on the results of such comparing. In yet further embodiments, such methods further include assessing the efficacy of medi cants, drugs and the like of a given treatment protocol such as by simulating in silico the application of such medicants, drugs and the like.
(FR)La présente invention concerne des procédés permettant une recherche des risques hémostatiques, y-compris le risque de syndrome coronarien aigu (ACS). Ces procédés consistent à acquérir une composition de plasma sanguin correspondant à échantillon biologique prélevé sur un sujet, à déterminer des paramètres en lien avec la coagulation sanguine, à simuler in vitro la coagulation sanguine au moyen des paramètres déterminés, à comparer à une référence le résultat d'une telle simulation, et enfin à déduire de cette comparaison le risque hémostatique. Pour d'autres modes de réalisation, de tels procédés consistent à se s'appuyer sur une telle comparaison pour sélectionner un schéma ou protocole thérapeutique. Pour encore d'autres modes de réalisation, de tels procédés consistent en plus à vérifier l'efficacité de médicaments, produits pharmaceutiques et analogues d'un protocole thérapeutique donné, notamment par simulation in vitro de l'application de tels médicaments, produits pharmaceutiques, et analogues.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)