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1. (WO2009142378) FULLERENE-SILICA NANOPARTICLES WITH IMPROVED FLUORESCENCE, PREPARATION METHOD THEREOF AND USE THEREOF
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2009/142378    International Application No.:    PCT/KR2009/000045
Publication Date: 26.11.2009 International Filing Date: 06.01.2009
IPC:
B82B 3/00 (2006.01)
Applicants: KOREA RESEARCH INSTITUTE OF BIOSCIENCE AND BIOTECHNOLOGY [KR/KR]; 111, Gwahangno Yuseong-gu Daejeon 305-806 (KR) (For All Designated States Except US).
CHUNG, Bong Hyun [KR/KR]; (KR) (For US Only).
JEONG, Jinyoung [KR/KR]; (KR) (For US Only).
SONG, Nam Woong [KR/KR]; (KR) (For US Only)
Inventors: CHUNG, Bong Hyun; (KR).
JEONG, Jinyoung; (KR).
SONG, Nam Woong; (KR)
Agent: LEE, Won-Hee; (KR)
Priority Data:
10-2008-0047070 21.05.2008 KR
Title (EN) FULLERENE-SILICA NANOPARTICLES WITH IMPROVED FLUORESCENCE, PREPARATION METHOD THEREOF AND USE THEREOF
(FR) NANOPARTICULES DE FULLERÈNE-SILICE À FLUORESCENCE AMÉLIORÉE, LEUR PROCÉDÉ DE PRÉPARATION ET LEUR UTILISATION
(KO) 형광특성이 향상된 풀러렌-실리카 나노입자, 이의 제조방법 및 이의 용도
Abstract: front page image
(EN)The present invention relates to fullerene-silica nanoparticles with improved fluorescence, a preparation method thereof and use thereof. More specifically, the present invention relates to fullerene-silica nanoparticles with improved fluorescence in which fullerene and silica are covalently linked, a preparation method of the fullerene-silica nanoparticles, and use thereof. The preparation method of the fullerene-silica nanoparticles comprises the steps of: adding a surfactant to a non-polar organic solvent and a polar solvent and stirring them to form reverse micelles (step 1); adding fullerene to the reverse micelles formed in step 1 and stirring them (step 2); and adding a silica precursor and a catalyst to a reaction solution containing the fullerene prepared in step 2 and stirring them to prepare fullerene-silica nanoparticles (step 3). According to the present invention, fullerene-silica nanoparticles in the form of a uniform spherical shape of tens of nanometers can be prepared. As such prepared fullerene-silica nanoparticles have a large surface area due to a nanometer-sized structure, they have good reactivity. Compared with heavy metals or metal nanoparticles, the fullerene-silica nanoparticles, because of using silica, are harmless to a living body. Further, as the fullerene-silica nanoparticles exhibit strong fluorescence, they can be used as a contrast agent for in-vivo imaging or as a drug delivery carrier.
(FR)La présente invention concerne des nanoparticules de fullerène-silice à fluorescence améliorée, leur procédé de préparation et leur utilisation. De manière plus spécifique, la présente invention concerne des nanoparticules de fullerène-silice à fluorescence améliorée sous forme de liaison covalente du fullerène et de la silice, un procédé de préparation des nanoparticules de fullerène-silice, et leur utilisation. Le procédé de préparation de nanoparticules de fullerène-silice comprend : l’addition d’un tensioactif à un solvant organique non polaire ou un solvant polaire et l’agitation du mélange pour former des micelles inverses (étape 1); l’addition de fullerène aux micelles inverses formées à l’étape 1 en les agitant (étape 2); et l’addition d’un précurseur de silice et d’un agent catalyseur à la solution de réaction contenant le fullerène préparé à l’étape 2 en les agitant pour préparer des nanoparticules de fullerène-silice (étape 3). Selon la présente invention, des nanoparticules de fullerène-silice ayant une forme sphérique de dizaines de nanomètres peuvent être préparées. De telles nanoparticules de fullerène-silice préparées présentent une grande surface grâce à une structure de taille nanométrique, et donc une bonne réactivité. Grâce à l’utilisation de silice, les nanoparticules de fullerène-silice ne sont pas nuisibles à un corps vivant comparées à d’autres nanoparticules de métaux lourds ou métalliques. Étant donné que les nanoparticules de fullerène-silice présentent une forte fluorescence, elles peuvent être utilisées comme agent de contraste pour l’imagerie in vivo ou comme un support d’administration de médicaments.
(KO)본 발명은 형광특성이 향상된 풀러렌-실리카 나노입자, 이의 제조방법 및 이의 용도에 관한 것으로, 구체적으로는 풀러렌과 실리카가 공유결합으로 연결되어 있는 형태를 포함하는 형광특성이 향상된 풀러렌-실리카 나노입자, 비극성 유기용매 및 극성 용매에 계면활성제를 넣고 교반하여 역마이셀을 형성시키는 단계(단계 1); 상기 단계 1에서 형성된 역마이셀에 풀러렌을 첨가하여 교반시키는 단계(단계 2); 및 상기 단계 2에서 제조된 풀러렌이 함유된 반응용액에 실리카 전구체 및 촉매제를 첨가하여 교반함으로써 풀러렌-실리카 나노입자를 제조하는 단계(단계 3)를 포함하는 풀러렌-실리카 나노입자의 제조방법 및 이의 용도에 관한 것이다. 본 발명에 따르면, 수십 나노미터 크기의 균일한 구형 모양을 형성하는 풀러렌-실리카 나노입자를 제조할 수 있고, 이렇게 제조된 풀러렌-실리카 나노입자는 나노미터 크기의 구조체로 인해 넓은 표면적을 가지므로 반응성이 좋고, 실리카를 이용함으로 중금속이나 금속 나노입자에 비해 생체에 무해하며, 강한 형광을 나타내므로 생체영상화 조영제 또는 약물전달체로서 유용하게 사용될 수 있다.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: Korean (KO)
Filing Language: Korean (KO)