Processing

Please wait...

Settings

Settings

1. WO2009141826 - NOVEL CONJUGATES OF POLYMERS HAVING A THERAPEUTICALLY ACTIVE AGENT AND AN ANGIOGENESIS TARGETING MOIETY ATTACHED THERETO AND USES THEREOF IN THE TREATMENT OF ANGIOGENESIS RELATED DISEASES

Publication Number WO/2009/141826
Publication Date 26.11.2009
International Application No. PCT/IL2009/000510
International Filing Date 21.05.2009
IPC
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
74
Synthetic polymeric materials
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
47
Medicinal preparations characterised by the non-active ingredients used, e.g. carriers, inert additives
48
the non-active ingredient being chemically bound to the active ingredient, e.g. polymer drug conjugates
C CHEMISTRY; METALLURGY
08
ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
G
MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
63
Macromolecular compounds obtained by reactions forming a carboxylic ester link in the main chain of the macromolecule
91
Polymers modified by chemical after-treatment
A61K 31/74 (2006.01)
A61K 47/48 (2006.01)
C08G 63/91 (2006.01)
CPC
A61K 31/336
A61K 31/337
A61K 47/50
A61K 47/62
A61K 47/65
G01N 2800/042
Applicants
  • RAMOT AT TEL AVIV UNIVERSITY LTD. [IL/IL]; P.O. Box 39296 61392 Tel-Aviv, IL (AllExceptUS)
  • FUNDACION DE LA COMUNIDAD VALENCIANA CENTRO DE INVESTIGACION PRINCIPE FELIPE [ES/ES]; Avda. Autopista del Saler 16-3 Camino de las Moreras (Junto al Oceanografico) E-46012 Valencia, ES (AllExceptUS)
  • SATCHI-FAINARO, Ronit [IL/IL]; IL (UsOnly)
  • VICENT DOCON, Maria Jesus [ES/ES]; ES (UsOnly)
Inventors
  • SATCHI-FAINARO, Ronit; IL
  • VICENT DOCON, Maria Jesus; ES
Agents
  • G.E. EHRLICH (1995) LTD.; 11 Menachem Begin Street 52521 Ramat Gan, IL
Priority Data
61/071,88622.05.2008US
61/193,14030.10.2008US
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) NOVEL CONJUGATES OF POLYMERS HAVING A THERAPEUTICALLY ACTIVE AGENT AND AN ANGIOGENESIS TARGETING MOIETY ATTACHED THERETO AND USES THEREOF IN THE TREATMENT OF ANGIOGENESIS RELATED DISEASES
(FR) NOUVEAUX CONJUGUÉS DE POLYMÈRES SUR LESQUELS SONT FIXÉS UN AGENT THÉRAPEUTIQUEMENT ACTIF ET UNE FRACTION CIBLANT L'ANGIOGENÈSE ET UTILISATIONS DE CES CONJUGUÉS POUR TRAITER DES MALADIES LIÉES À L'ANGIOGENÈSE
Abstract
(EN)
Conjugates of a polymer having attached thereto an angiogenesis targeting moiety and a therapeutically active agent such as an anti-cancer agent or anti-angiogenesis agent, and processes of preparing same are disclosed. Pharmaceutical compositions containing these conjugates and uses thereof in the treatment of angiogenesis-related medical conditions such as cancer and cancer metastases are also disclosed.
(FR)
L'invention concerne des conjugués d'un polymère sur lequel sont fixés une fraction ciblant l'angiogenèse et un agent thérapeutiquement actif, tel qu'un agent anticancéreux ou un agent anti-angiogenèse, ainsi que des procédés de préparation de ces conjugués. L'invention concerne également des compositions pharmaceutiques contenant ces conjugués et des utilisations de ceux-ci pour traiter des états pathologiques liés à l'angiogenèse, tels qu'un cancer et des métastases de cancer.
Latest bibliographic data on file with the International Bureau