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1. (WO2009141418) FORMULATIONS OF PEG-FUNCTIONALISED SERINE PROTEASES WITH HIGH CONCENTRATIONS OF AN AROMATIC PRESERVATIVE
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2009/141418    International Application No.:    PCT/EP2009/056210
Publication Date: 26.11.2009 International Filing Date: 22.05.2009
IPC:
A61K 47/10 (2006.01), A61K 9/08 (2006.01), A61K 38/48 (2006.01), A61P 7/04 (2006.01)
Applicants: NOVO NORDISK HEALTH CARE AG [CH/CH]; Andreasstrasse 15 CH-8050 Zurich (CH) (For All Designated States Except US).
RISCHEL, Christian [DK/DK]; (DK) (For US Only).
NIELSEN, Anders Dybdal [DK/DK]; (DK) (For US Only).
JENSEN, Michael Bech [DK/DK]; (DK) (For US Only)
Inventors: RISCHEL, Christian; (DK).
NIELSEN, Anders Dybdal; (DK).
JENSEN, Michael Bech; (DK)
Priority Data:
08104071.9 23.05.2008 EP
08168826.9 11.11.2008 EP
Title (EN) FORMULATIONS OF PEG-FUNCTIONALISED SERINE PROTEASES WITH HIGH CONCENTRATIONS OF AN AROMATIC PRESERVATIVE
(FR) FORMULATIONS DE SÉRINES PROTÉASES FONCTIONNALISÉES PAR PEG AVEC DES CONCENTRATIONS ÉLEVÉES D'UN CONSERVATEUR AROMATIQUE
Abstract: front page image
(EN)The invention relates to a liquid, aqueous pharmaceutical composition comprising a Factor VII polypeptide (i) functionalised with one or more polyethylene glycol (PEG) moieties, said PEG moieties having a molecular weight of at least 300 Da; a buffering agent (ii) suitable for keeping pH in the range of from about 5.0 to about 9.0; and at least one aromatic preservative (iii) in a concentration of at least 0.1 mg/mL.
(FR)L'invention porte sur un liquide, sur une composition pharmaceutique aqueuse comportant un polypeptide de facteur VII (i) fonctionnalisé par une ou plusieurs fractions de polyéthylène glycol (PEG), lesdites fractions PEG ayant une masse moléculaire d'au moins 300 Da; un agent de tamponnage (ii) approprié pour maintenir le pH dans la plage d'environ 5,0 à environ 9,0, et au moins un conservateur aromatique (iii) dans une concentration d'au moins 0,1 mg/ml.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)