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Pub. No.:    WO/2009/140928    International Application No.:    PCT/CN2009/071967
Publication Date: 26.11.2009 International Filing Date: 25.05.2009
C07D 403/06 (2006.01), A61K 31/404 (2006.01), A61P 35/00 (2006.01), A61P 25/00 (2006.01), A61P 29/00 (2006.01), A61P 37/00 (2006.01), A61P 9/00 (2006.01)
Applicants: SHANGHAI INSTITUTE OF PHARMACEUTICAL INDUSTRY [CN/CN]; No. 1320 Beijing West Road Shanghai 200040 (CN) (For All Designated States Except US).
JIANGSU CHIATAI TIANQING PHARMACEUTICAL CO., LTD. [CN/CN]; No. 8 Julong North Road, Xinpu Lianyungang, Jiangsu 222006 (CN) (For All Designated States Except US).
YUAN, Zhedong [CN/CN]; (CN) (For US Only).
ZHANG, Xiaomin [CN/CN]; (CN) (For US Only).
WANG, Hubo [CN/CN]; (CN) (For US Only).
ZHU, Xueyan [CN/CN]; (CN) (For US Only).
XU, Hongjiang [CN/CN]; (CN) (For US Only).
FU, Hui [CN/CN]; (CN) (For US Only).
SONG, Wei [CN/CN]; (CN) (For US Only)
Inventors: YUAN, Zhedong; (CN).
ZHANG, Xiaomin; (CN).
WANG, Hubo; (CN).
ZHU, Xueyan; (CN).
XU, Hongjiang; (CN).
FU, Hui; (CN).
SONG, Wei; (CN)
Agent: INSIGHT INTELLECTUAL PROPERTY LIMITED; Suite 19A, 19B, Tower A InDo Building No. 48A Zhichun Road Haidian District Beijing 100098 (CN)
Priority Data:
200810098055.5 23.05.2008 CN
(ZH) 二氢吲哚酮衍生物
Abstract: front page image
(EN)Dihydroindolinone compounds which may modulate the activity of protein tyrosine kinases, their preparation methods, compositions comprising the compounds and the uses of the compounds and compositions described herein in the treatment or prevention of protein tyrosine kinases related diseases in organism, particularly cancer and the proliferation of fibroblast related diseases.
(FR)L'invention porte sur des composés de dihydroindolinone qui peuvent moduler l'activité de protéines tyrosine kinases, sur leur procédé de fabrication, sur des compositions comprenant les composés et sur les utilisations des composés et compositions décrits ici dans le traitement ou la prévention de maladies liées aux protéines tyrosine kinases dans l'organisme, en particulier d'un cancer et des maladies liées à la prolifération de fibroblastes.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: Chinese (ZH)
Filing Language: Chinese (ZH)