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1. (WO2009140743) BLOOD IMAGING
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2009/140743    International Application No.:    PCT/BE2009/000027
Publication Date: 26.11.2009 International Filing Date: 25.05.2009
A61K 51/04 (2006.01), C07C 311/37 (2006.01), C07F 1/08 (2006.01), C07F 5/00 (2006.01), C07F 13/00 (2006.01)
Applicants: Katholieke Universiteit Leuven [BE/BE]; K.U. Leuven R&D Minderbroedersstraat 8A - bus 5105 B-3000 Leuven (BE) (For All Designated States Except US).
BORMANS, Guy [BE/BE]; (BE) (For US Only).
VERBRUGGEN, Alfons [BE/BE]; (BE) (For US Only)
Inventors: BORMANS, Guy; (BE).
Agent: Katholieke Universiteit Leuven; K.U. Leuven R&D Minderbroedersstraat 8A - bus 5105 B-3000 leuven (BE)
Priority Data:
61/128624 23.05.2008 US
Abstract: front page image
(EN)The invention generally relates to the application of imaging techniques, in particular positron emission tomography (PET) or single photon emission tomography (SPECT), in the assessment of physiological parameters in a subject. The compounds of the present invention were shown to be cell membrane permeant and to have a specific binding affinity (or substrate affinity) for the carbonic anhydrases type I and II, and are accordingly useful for the in vivo and in vitro labeling of erythrocytes (RBC). It is accordingly an object of the present invention to provide said novel compounds, in particular the radio labeled variants thereof, and their use in imaging techniques to perform the assessment of physiological parameters, such as blood volume measurements, or blood flow measurements.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)