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1. (WO2009140699) ASTHMA SUSCEPTIBILITY LOCI LOCATED AT CHROMOSOME 1q31 FOR USE IN DIAGNOSTIC AND THERAPEUTIC METHODS
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2009/140699    International Application No.:    PCT/US2009/044412
Publication Date: 19.11.2009 International Filing Date: 18.05.2009
IPC:
C12P 19/34 (2006.01)
Applicants: THE CHILDREN'S HOSPITAL OF PHILADELPHIA [US/US]; Abramson Pediatric Research Center Office of Technology Transfer 3615 Civic Center Blvd, Room 141 Philadelphia, PA 19104 (US) (For All Designated States Except US).
HAKONARSON, Hakon [IS/US]; (US) (For US Only).
SLEIMAN, Patrick, M., A. [IE/US]; (US) (For US Only)
Inventors: HAKONARSON, Hakon; (US).
SLEIMAN, Patrick, M., A.; (US)
Agent: RIGAUT, Kathleen, D.; (US)
Priority Data:
61/053,808 16.05.2008 US
Title (EN) ASTHMA SUSCEPTIBILITY LOCI LOCATED AT CHROMOSOME 1q31 FOR USE IN DIAGNOSTIC AND THERAPEUTIC METHODS
(FR) LOCI DE SUSCEPTIBILITÉ À L'ASTHME SITUÉS AU NIVEAU DU CHROMOSOME 1Q31 DESTINÉS À ÊTRE UTILISÉS DANS DES MÉTHODES DIAGNOSTIQUES ET THÉRAPEUTIQUES
Abstract: front page image
(EN)Methods and composition are provided for diagnosing pediatπc onset asthma based on the single nucleotide polymorphism on chromosome 1q31 wherein said single nucleotide polymorphism is set forth in Table 2 or Table 6 of the instant invention Method and composition are also provided for treating and preventing asthma or other inflammatory conditions in a patient in need thereof compπsing administering an effective amount of an at least one inhibitor which reduces the expression of DENND1 B gene product.
(FR)L'invention concerne des compositions et des méthodes pour la détection et le traitement de l'asthme.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)