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1. (WO2009140685) METHODS FOR IDENTIFYING SUBJECTS WITH AN INCREASED LIKELIHOOD OF RESPONDING TO DPP-IV INHIBITORS
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2009/140685    International Application No.:    PCT/US2009/044376
Publication Date: 19.11.2009 International Filing Date: 18.05.2009
IPC:
C12Q 1/68 (2006.01)
Applicants: BRISTOL-MYERS SQUIBB COMPANY [US/US]; Route 206 & Province Line Road Princeton, NJ 08543 (US) (For All Designated States Except US).
ASTRAZENECA UK LIMITED [GB/GB]; 15 Stanhope Gate, London W1K 1LN (GB) (For All Designated States Except US).
EMISON, Eileen [US/US]; (US) (For US Only).
DELMONTE, Terrye, Aigeldinger [US/US]; (US) (For US Only).
RANADE, Koustubh [IN/US]; (US) (For US Only).
RODRIGUEZ, Lisa, Renee [US/US]; (US) (For US Only).
SIMONSEN, Katy, Lynn Moore [US/US]; (US) (For US Only)
Inventors: EMISON, Eileen; (US).
DELMONTE, Terrye, Aigeldinger; (US).
RANADE, Koustubh; (US).
RODRIGUEZ, Lisa, Renee; (US).
SIMONSEN, Katy, Lynn Moore; (US)
Agent: PILLAI, Suresh, B.; (US)
Priority Data:
61/054,098 16.05.2008 US
Title (EN) METHODS FOR IDENTIFYING SUBJECTS WITH AN INCREASED LIKELIHOOD OF RESPONDING TO DPP-IV INHIBITORS
(FR) PROCÉDÉS D'IDENTIFICATION DE SUJETS À FORTE PROBABILITÉ DE RÉACTION À DES INHIBITEURS DE DPP-IV
Abstract: front page image
(EN)The invention provides novel in vitro diagnostic methods for identifying subjects or patients who may have an increased likelihood of responding to DPP-IV inhibitor therapy. The invention also provides novel polynucleotides associated with increased responsiveness of a patient to DPP-IV inhibition. Polynucleotide fragments which comprise at least one polymorphic locus, are also provided. Allele-specific primers and probes which hybridize to these polymorphic regions, and/or which comprise at least one polymorphic locus are also provided. The polynucleotides, primers, and probes of the invention are useful in phenotype correlations, medicine, and genetic analysis.
(FR)L'invention concerne de nouveaux procédés de diagnostic in vitro d'identification de sujets ou de patients pouvant présenter une forte probabilité de réaction à une thérapie d'inhibiteurs de DPP-IV. L'invention propose également de nouveaux polynucléotides associés à la réaction accrue d'un patient à l'inhibition de DPP-IV, ainsi que des fragments de polynucléotides correspondant à au moins un locus polymorphe. Des amorces et des sondes spécifiques aux allèles qui s'hybrident au niveau de ces régions polymorphes et/ou qui comprennent au moins un locus polymorphe sont également proposées. Les polynucléotides, les amorces et les sondes de la présente invention sont utiles dans les corrélations du phénotype, la médecine et l'analyse génétique.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)