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Pub. No.:    WO/2009/140599    International Application No.:    PCT/US2009/044149
Publication Date: 19.11.2009 International Filing Date: 15.05.2009
A61K 38/17 (2006.01), A61K 47/48 (2006.01), A61K 51/08 (2006.01), A61P 35/04 (2006.01)
Applicants: TRANSMOLECULAR, INC. [US/US]; 840 Memorial Drive, Second Floor Cambridge, MA 02139 (US) (For All Designated States Except US).
O'NEILL, Alison [US/US]; (US) (For US Only).
JACOBY, Douglas, B. [US/US]; (US) (For US Only).
SENTISSI, Abdellah [US/US]; (US) (For US Only).
KESAVAN, Kamala [IN/US]; (US) (For US Only).
EGAN, E., Michael [US/US]; (US) (For US Only)
Inventors: O'NEILL, Alison; (US).
JACOBY, Douglas, B.; (US).
SENTISSI, Abdellah; (US).
KESAVAN, Kamala; (US).
EGAN, E., Michael; (US)
Agent: NGUYEN, Suzanne; (US)
Priority Data:
61/173,121 27.04.2009 US
61/053,651 15.05.2008 US
61/153,273 17.02.2009 US
Abstract: front page image
(EN)The present invention is directed to methods and methods for the treatment, inhibition and/or reduction, and detection of metastatic tumors. In some embodiments, the inventive methods include systemic (e.g., intravenous) administration of a chlorotoxin agent that may or may not be labeled. In some embodiments, the inventive methods allow treatment, inhibition and/or reduction, and detection of metastases in the brain. In some embodiments, neovascularization is inhibited and/or newly formed vessels are caused to regress.
(FR)La présente invention concerne des procédés de traitement, d'inhibition et/ou de réduction, ainsi que de détection de tumeurs métastatiques. Dans certains modes de réalisation, les procédés de l'invention comprennent l'administration systémique (par exemple par voie intraveineuse) d'un agent de type chlorotoxine qui peut ou pas être marqué. Dans certains modes de réalisation, les procédés de l'invention permettent le traitement, l'inhibition et/ou la réduction, ainsi que la détection de métastases dans le cerveau. Dans certains modes de réalisation, la néovascularisation est inhibée et/ou les vaisseaux nouvellement formés sont amenés à régresser.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)