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Pub. No.:    WO/2009/140467    International Application No.:    PCT/US2009/043905
Publication Date: 19.11.2009 International Filing Date: 14.05.2009
A01N 43/42 (2006.01), A61K 31/47 (2006.01)
Applicants: PURDUE RESEARCH FOUNDATION [US/US]; 1281 Win Hentschel Blvd. West Lafayette, IN 47906 (US) (For All Designated States Except US).
CUSHMAN, Mark, S. [US/US]; (US) (For US Only).
THE GOVERNMENT OF THE UNITED STATES OF AMERICA, as represented by THE SECRETARY OF THE DEPARTENT OF HEALTH & HUMAN SERVICES [US/US]; National Institutees Of Health 6011 Executive Boulevard Suite 325 Bethesda, MD 20852 (US) (For All Designated States Except US).
CINELLI, Maris, A. [US/US]; (US) (For US Only).
MORRELL, Andrew, E. [US/US]; (US) (For US Only).
POMMIER, Yves, G. [US/US]; (US) (For US Only)
Inventors: CUSHMAN, Mark, S.; (US).
CINELLI, Maris, A.; (US).
MORRELL, Andrew, E.; (US).
POMMIER, Yves, G.; (US)
Agent: ADDISON, Bradford, G.; (US)
Priority Data:
61/053,338 15.05.2008 US
Abstract: front page image
(EN)The synthesis of aromathecins, substituted 12H-5,l la-diazadibenzo[b,h]fluoren- 11 -ones is described. Use of these cytotoxic compounds and pharmaceutical compositions containing them for the treatment of cancer is described. Two novel processes for the synthesis of this system and a series of 14-substituted aromathecins as novel cytotoxic, topoisomerase I poisons are described.
(FR)L'invention porte sur la synthèse d'aromathécines, 12H-5,11a-diazadibenzo[b,h]fluorén-11–ones substituées. L'invention porte également sur l'utilisation de ces composés cytotoxiques et de compositions pharmaceutiques les contenant pour le traitement du cancer. L'invention porte aussi sur deux nouveaux procédés pour la synthèse de ce système et une série d'aromathécines substituées en position 14 comme nouveaux poisons de topoisomérase I, cytotoxiques.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)