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1. (WO2009140457) COMBINATIONS OF ANTIOXIDANTS AND ANTI-INFLAMMATORY DRUGS IN THE OF TREATMENT INFLAMMATORY BOWEL DISEASE
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2009/140457    International Application No.:    PCT/US2009/043892
Publication Date: 19.11.2009 International Filing Date: 14.05.2009
IPC:
A01N 57/10 (2006.01), A01N 37/36 (2006.01), A61K 31/66 (2006.01)
Applicants: THE BOARD OF REGENTS OF THE UNIVERSITY OF OKLAHOMA [US/US]; Room 119 660 Parrington Oval Norman, OK 73019 (US) (For All Designated States Except US).
HARTY, Richard, F. [US/US]; (US) (For US Only)
Inventors: HARTY, Richard, F.; (US)
Agent: TAHMASSEBI, Sam, K.; (US)
Priority Data:
61/053,473 15.05.2008 US
Title (EN) COMBINATIONS OF ANTIOXIDANTS AND ANTI-INFLAMMATORY DRUGS IN THE OF TREATMENT INFLAMMATORY BOWEL DISEASE
(FR) ASSOCIATIONS D'ANTIOXYDANTS ET DE MÉDICAMENTS ANTI-INFLAMMATOIRES DANS LE TRAITEMENT D'UNE MALADIE INTESTINALE INFLAMMATOIRE
Abstract: front page image
(EN)Disclosed herein are compositions comprising 5-aminosalicylic acid (5-ASA), or a pharmaceutically acceptable salt thereof and an antioxidant, or a pharmaceutically acceptable salt thereof. Also disclosed herein are methods of treating an inflammatory bowel disease in a subject, reducing cytokine gene expression in colonic tissue of a subject, and reducing myeloperoxide activity in colonic tissue of a subject, comprising administering to the subject a therapeutically-effective amount of a composition comprising 5-ASA, or a pharmaceutically-acceptable salt thereof, and an antioxidant, or a pharmaceutically acceptable salt thereof.
(FR)L'invention porte sur des compositions comprenant de l'acide 5-aminosalicylique (5-ASA), ou un sel pharmaceutiquement acceptable de celui-ci, et un antioxydant, ou un sel pharmaceutiquement acceptable de celui-ci. L'invention porte également sur des procédés de traitement d'une maladie intestinale inflammatoire chez un sujet, de réduction de l'expression de gènes de cytokines dans un tissu du côlon d'un sujet et de réduction de l'activité de myéloperoxydes dans un tissu du côlon d'un sujet, comprenant l'administration au sujet d'une quantité thérapeutiquement efficace d'une composition comprenant du 5-ASA, ou un sel pharmaceutiquement acceptable de celui-ci, et un antioxydant, ou un sel pharmaceutiquement acceptable de celui-ci.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)