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1. (WO2009140383) APTAMERS THAT BIND TO P-SELECTIN AND THEIR USE AS COAGULATION, THROMBOTIC, INFLAMMATORY, AND METASTATIC DISEASE THERAPEUTICS

Pub. No.:    WO/2009/140383    International Application No.:    PCT/US2009/043787
Publication Date: Nov 19, 2009 International Filing Date: May 13, 2009
IPC: C07H 21/02
A61K 31/7088
Applicants: ARCHEMIX CORP.
SCHAUB, Robert
KURZ, Jeffrey
Inventors: SCHAUB, Robert
KURZ, Jeffrey
Title: APTAMERS THAT BIND TO P-SELECTIN AND THEIR USE AS COAGULATION, THROMBOTIC, INFLAMMATORY, AND METASTATIC DISEASE THERAPEUTICS
Abstract:
Materials and methods are provided to prepare targeting nucleic acids and more particularly to aptamers that bind to P-selectin, which are useful as therapeutics in and diagnostics of coagulation/thrombotic, inflammatory, metastatic and/or other pathologies, diseases or disorders in which P-selectin has been implicated. In addition, the aptamers may be used before, during and/or after medical procedures to reduce complications or side effects thereof. Materials and methods for the administration of aptamers that bind to P-selectin are also provided.