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1. (WO2009140326) MICROFLUIDIC ISOLATION OF TUMOR CELLS OR OTHER RARE CELLS FROM WHOLE BLOOD OR OTHER LIQUIDS
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2009/140326    International Application No.:    PCT/US2009/043697
Publication Date: 19.11.2009 International Filing Date: 13.05.2009
IPC:
C12M 3/00 (2006.01), G01N 33/574 (2006.01), A61P 35/00 (2006.01), C12N 7/00 (2006.01)
Applicants: BOARD OF SUPERVISORS OF LOUISIANA STATE UNIVERSITY AND AGRICULTURAL AND MECHANICAL COLLEGE [US/US]; Office Of Intellectual Property 206 Emerging Technology Center Baton Rouge, LA 70803 (US) (For All Designated States Except US).
SOPER, Steven, A. [US/US]; (US) (For US Only).
MURPHY, Michael, C. [US/US]; (US) (For US Only).
FENG, Juan [CN/US]; (US) (For US Only).
MCCARLEY, Robin, L. [US/US]; (US) (For US Only).
ADAMS, Andre, A. [US/US]; (US) (For US Only)
Inventors: SOPER, Steven, A.; (US).
MURPHY, Michael, C.; (US).
FENG, Juan; (US).
MCCARLEY, Robin, L.; (US).
ADAMS, Andre, A.; (US)
Agent: RUNNELS, John, H.; (US)
Priority Data:
61/053,727 16.05.2008 US
Title (EN) MICROFLUIDIC ISOLATION OF TUMOR CELLS OR OTHER RARE CELLS FROM WHOLE BLOOD OR OTHER LIQUIDS
(FR) ISOLEMENT MICROFLUIDIQUE DE CELLULES TUMORALES OU AUTRES CELLULES RARES À PARTIR DE SANG ENTIER OU AUTRES LIQUIDES
Abstract: front page image
(EN)Microdevices are disclosed to efficiently, accurately, and rapidly isolate and enumerate rare cells, such as circulating tumor cells, from liquids such as whole blood. The system employs multiple parallel meandering channels having a width on the order of 1 -2 cell diameters. The microdevices can be produced at low-cost, may readily be automated, and in many instances may be used without pre-processing of the sample. They may be used to isolate and enumerate rare cells, including for example the detection and diagnosis of cancers, cancer staging, or evaluating the effectiveness of a therapeutic intervention, or detecting pathogenic bacteria. The device may optionally be used to nondestructively capture and later to release target cells.
(FR)L'invention porte sur des microdispositifs pour isoler et énumérer de façon efficace, précise et rapide des cellules rares, telles que des cellules tumorales circulantes, à partir de liquides tels que le sang complet. Le système emploie de multiples canaux serpentant en parallèle ayant une largeur de l'ordre de 1-2 diamètres de cellule. Les microdispositifs peuvent être produits à moindre coût, peuvent facilement être automatisés et dans de nombreux cas peuvent être utilisés sans prétraitement de l'échantillon. Ils peuvent être utilisés pour isoler et énumérer des cellules rares, comprenant par exemple la détection et le diagnostic de cancers, la stadification de cancer ou l'évaluation de l'efficacité d'une intervention thérapeutique, ou la détection de bactéries pathogènes. Le dispositif peut facultativement être utilisé pour capturer de façon non destructive puis libérer des cellules cibles.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)