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1. (WO2009140287) SALINOSPORAMIDE DERIVATIVES AS PROTEASOME INHIBITORS
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2009/140287    International Application No.:    PCT/US2009/043644
Publication Date: 19.11.2009 International Filing Date: 12.05.2009
Chapter 2 Demand Filed:    12.03.2010    
IPC:
C07D 491/044 (2006.01), A61K 31/655 (2006.01), A61P 31/04 (2006.01), A61K 31/407 (2006.01), A61P 29/00 (2006.01), A61P 35/00 (2006.01)
Applicants: NEREUS PHARMACEUTICALS, INC. [US/US]; 10480 Wateridge Circle San Diego, CA 92121 (US) (For All Designated States Except US).
MACHERLA, Venkat, Rami Reddy [IN/US]; (US) (For US Only).
POTTS, Barbara, Christine [US/US]; (US) (For US Only).
MANAM, Rama, Rao [IN/US]; (US) (For US Only).
MCARTHUR, Katherine, A. [US/US]; (US) (For US Only).
CHAO, Ta-Hsiang [US/US]; (US) (For US Only).
NEUTEBOOM, Saskia, Theodora Cornelia [NL/US]; (US) (For US Only)
Inventors: MACHERLA, Venkat, Rami Reddy; (US).
POTTS, Barbara, Christine; (US).
MANAM, Rama, Rao; (US).
MCARTHUR, Katherine, A.; (US).
CHAO, Ta-Hsiang; (US).
NEUTEBOOM, Saskia, Theodora Cornelia; (US)
Agent: MALLON, Joseph, J.; Knobbe Martens Olson & Bear LLP 2040 Main Street 14th Floor Irvine, CA 92614 (US)
Priority Data:
61/052,576 12.05.2008 US
Title (EN) SALINOSPORAMIDE DERIVATIVES AS PROTEASOME INHIBITORS
(FR) DÉRIVÉS DE SALINOSPORAMIDE À UTILISER EN TANT QU'INHIBITEURS DES PROTÉASOMES
Abstract: front page image
(EN)Disclosed herein are 6-oxa-2-azabicyclo[3.2.0]heptane-3,7-dione or heterobicyclic γ-lactam-β-lactone derivatives of formula (I) that include a sulfonate ester, ester or ether group in the substituent at the 4-position as proteasome inhibitors. These Salinosporamide derivatives of formula (I) can be included in pharmaceutical compositions and can be used for treating or ameliorating a disease or condition such as cancer, a microbial disease or inflammation.
(FR)La présente invention concerne des dérivés de 6-oxa-2-azabicyclo[3.2.0]heptane-3,7-dione ou γ-lactam-β-lactone hétérobicycliques de formule (I) qui comprennent un groupe ester de sulfonate, ester ou éther dans le substituant en position 4 en tant qu'inhibiteurs des protéasomes. Ces dérivés de salinosporamide de formule (I) peuvent être inclus dans des compositions pharmaceutiques et peuvent être utilisés pour traiter et/ou améliorer une maladie ou une pathologie telle que le cancer, une maladie microbienne et/ou une inflammation.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)