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1. (WO2009140242) ANALYSIS OF ANTIBODY DRUG CONJUGATES BY BEAD-BASED AFFINITY CAPTURE AND MASS SPECTROMETRY
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2009/140242    International Application No.:    PCT/US2009/043560
Publication Date: 19.11.2009 International Filing Date: 12.05.2009
IPC:
G01N 33/50 (2006.01)
Applicants: GENENTECH, INC. [US/US]; 1 DNA Way South San Francisco, CA 94080 (US) (For All Designated States Except US).
KAUR, Surinder [US/US]; (US) (For US Only).
SAAD, Ola [US/US]; (US) (For US Only).
XU, Keyang [US/US]; (US) (For US Only)
Inventors: KAUR, Surinder; (US).
SAAD, Ola; (US).
XU, Keyang; (US)
Agent: ANDRUS, Alex; (US)
Priority Data:
61/052,727 13.05.2008 US
Title (EN) ANALYSIS OF ANTIBODY DRUG CONJUGATES BY BEAD-BASED AFFINITY CAPTURE AND MASS SPECTROMETRY
(FR) ANALYSE DE CONJUGUÉS ANTICORPS-MÉDICAMENT PAR CAPTURE D'AFFINITÉ À BASE DE BILLE ET SPECTROMÉTRIE DE MASSE
Abstract: front page image
(EN)Methods to detect, characterize, and quantitate biological samples after administration of antibody conjugates, antibody-drug conjugates of Formula I, antibodies, and fragments and metabolites thereof, by immunoaffinity bead separation, chromatography, and mass spectrometry are disclosed. Ab-(L-D)p wherein Ab is an antibody; D is a drug moiety; L is a linker covalently attached to Ab, and covalently attached to D; and p is 1, 2, 3, 4, 5, 6, 7, or 8.
(FR)L'invention porte sur des procédés pour détecter, caractériser et quantifier des échantillons biologiques après administration de conjugués d'anticorps, de conjugués anticorps-médicament de Formule I, d'anticorps et de fragments et de métabolites de ceux-ci, par séparation de bille par immunoaffinité, chromatographie et spectrométrie de masse. Ab-(L-D)p, formule dans laquelle Ab est un anticorps; D est une fraction de médicament; L est un liant lié de façon covalente à Ab, et lié de façon covalente à D; et p est 1, 2, 3, 4, 5, 6, 7 ou 8.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)