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1. (WO2009140166) OXAZOLOBENZIMIDAZOLE DERIVATIVES
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2009/140166    International Application No.:    PCT/US2009/043324
Publication Date: 19.11.2009 International Filing Date: 08.05.2009
IPC:
A61K 31/535 (2006.01)
Applicants: MERCK SHARP & DOHME CORP. [US/US]; 126 East Lincoln Avenue Rahway, NJ 07065-0907 (US) (For All Designated States Except US).
BRNARDIC, Edward, J. [CA/US]; (US) (For US Only).
FRALEY, Mark, E. [US/US]; (US) (For US Only).
GARBACCIO, Robert, M. [US/US]; (US) (For US Only)
Inventors: BRNARDIC, Edward, J.; (US).
FRALEY, Mark, E.; (US).
GARBACCIO, Robert, M.; (US)
Common
Representative:
MERCK SHARP & DOHME CORP.; 126 East Lincoln Avenue Rahway, NJ 07065-0907 (US)
Priority Data:
61/127,733 15.05.2008 US
Title (EN) OXAZOLOBENZIMIDAZOLE DERIVATIVES
(FR) DÉRIVÉS D'OXAZOLOBENZIMIDAZOLE
Abstract: front page image
(EN)The present invention is directed to oxazolobenzimidazole derivatives which are potentiators of metabotropic glutamate receptors, particularly the mGluR2 receptor, and which are useful in the treatment or prevention of neurological and psychiatric disorders associated with glutamate dysfunction and diseases in which metabotropic glutamate receptors are involved. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which metabotropic glutamate receptors are involved.
(FR)La présente invention concerne des dérivés d'oxazolobenzimidazole qui sont des potentialisateurs des récepteurs métabotropiques du glutamate, en particulier le récepteur mGluR2, et sont utiles dans le traitement ou la prévention de troubles neurologiques ou psychiatriques associés au dysfonctionnement du glutamate, et de maladies dans lesquelles interviennent les récepteurs métabotropiques du glutamate. L’invention concerne également des compositions pharmaceutiques comprenant ces composés et l'utilisation de ces composés et compositions pour la prévention ou le traitement de telles maladies dans lesquelles interviennent les récepteurs métabotropiques du glutamate.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)