WIPO logo
Mobile | Deutsch | Español | Français | 日本語 | 한국어 | Português | Русский | 中文 | العربية |
PATENTSCOPE

Search International and National Patent Collections
World Intellectual Property Organization
Search
 
Browse
 
Translate
 
Options
 
News
 
Login
 
Help
 
Machine translation
1. (WO2009140162) STABLE PHARMACEUTICAL FORMULATIONS
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2009/140162    International Application No.:    PCT/US2009/043295
Publication Date: 19.11.2009 International Filing Date: 08.05.2009
Chapter 2 Demand Filed:    11.03.2010    
IPC:
A61K 9/00 (2006.01), A61K 47/10 (2006.01), A61K 47/40 (2006.01)
Applicants: BAXTER INTERNATIONAL INC. [US/US]; One Baxter Parkway Deerfield, Illinois 60015 (US) (For All Designated States Except US).
BAXTER HEALTHCARE S.A. [CH/CH]; Thurgauerstrasse 130 CH-8152 Glattpark (Opfikon) (CH) (For All Designated States Except US).
KIPP, James, E. [US/US]; (US) (For US Only).
WONG, Joseph, C., T. [US/US]; (US) (For US Only).
NAIR, Lakshmy [US/US]; (US) (For US Only).
MILLER, Reagan [US/US]; (US) (For US Only).
RABINOW, Barrett, E. [US/US]; (US) (For US Only)
Inventors: KIPP, James, E.; (US).
WONG, Joseph, C., T.; (US).
NAIR, Lakshmy; (US).
MILLER, Reagan; (US).
RABINOW, Barrett, E.; (US)
Agent: BECKETT, Michael, A.; K&L GATES LLP c/o Foreign Patents P.O.Box 1135 Chicago, IL 60690-1135 (US)
Priority Data:
61/053,301 15.05.2008 US
Title (EN) STABLE PHARMACEUTICAL FORMULATIONS
(FR) FORMULATIONS PHARMACEUTIQUES STABLES
Abstract: front page image
(EN)Stable pharmaceutical formulations and methods of making same are provided. In a general embodiment, the present disclosure provides a method of making a stable pharmaceutical formulation comprising adding one or more vitrifying additives to an aqueous pharmaceutical solution to raise the glass transition temperature of the aqueous pharmaceutical solution. The aqueous pharmaceutical solution can be cooled to a temperature of about -50 C to about -10 C. The vitrifying additive enhances the formation of a glass or amorphous solid of the aqueous pharmaceutical solution at cryogenic temperatures (-50 to -10C), and the pharmaceutical formulation can be thawed to liquid form and administered to a mammalian subject.
(FR)La présente invention concerne des formulations pharmaceutiques stables, et des procédés de fabrication correspondants. Un mode de réalisation général de la présente invention concerne un procédé de fabrication d'une formulation pharmaceutique stable en ajoutant à une solution pharmaceutique aqueuse un ou plusieurs additifs vitrificateurs de façon à augmenter la température de transition vitreuse de la solution pharmaceutique aqueuse. La solution pharmaceutique aqueuse peut être refroidie jusqu'à une température se situant dans une plage d'environ -50°C à -10°C. L'additif vitrificateur améliore la vitrification ou la solidification amorphe de la solution pharmaceutique aqueuse à des températures cryogènes (-50°C à -10°C), la formulation pharmaceutique pouvant se liquéfier par décongélation et s'administrer à un sujet mammifère.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)