WIPO logo
Mobile | Deutsch | Español | Français | 日本語 | 한국어 | Português | Русский | 中文 | العربية |
PATENTSCOPE

Search International and National Patent Collections
World Intellectual Property Organization
Search
 
Browse
 
Translate
 
Options
 
News
 
Login
 
Help
 
Machine translation
1. (WO2009140127) SYNTHESIS OF DIHYDROTHIENO[3,2-d]PYRIMIDINE DIOLS AND SIMILAR PYRIMIDINE DIOLS
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2009/140127    International Application No.:    PCT/US2009/043068
Publication Date: 19.11.2009 International Filing Date: 07.05.2009
IPC:
C07D 239/70 (2006.01), C07D 495/04 (2006.01)
Applicants: BOEHRINGER INGELHEIM INTERNATIONAL GMBH [DE/DE]; Boehringer Ingelheim International Gmbh Bingerstrasse 173 D-55216 Ingelheim (DE) (AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BE, BF, BG, BH, BJ, BR, BW, BY, BZ, CA, CF, CG, CH, CI, CM, CN, CO, CR, CU, CY, CZ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, FR, GA, GB, GD, GE, GH, GM, GN, GQ, GR, GT, GW, HN, HR, HU, ID, IE, IL, IN, IS, IT, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LV, LY, MA, MC, MD, ME, MG, MK, ML, MN, MR, MT, MW, MX, MY, MZ, NA, NE, NG, NI, NL, NO, NZ, OM, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SI, SK, SL, SM, SN, ST, SV, SY, SZ, TD, TG, TJ, TM, TN, TR, TT, TZ, UA, UG, UZ, VC, VN, ZA, ZM, ZW only).
BOEHRINGER INGELHEIM PHARMA GMBH & CO. KG [DE/DE]; Boehringer Ingelheim Pharma Gmbh & Co. KG Bingerstrasse 173 D-55216 Ingelheim (DE) (DE only).
FRUTOS, Rogelio, Perez [US/US]; (US) (For US Only).
TAMPONE, Thomas, G. [US/US]; (US) (For US Only).
MULDER, Jason, Alan [US/US]; (US) (For US Only).
KRISHNAMURTHY, Dhileepkumar [US/US]; (US) (For US Only).
SENANAYAKE, Chris, Hugh [US/US]; (US) (For US Only)
Inventors: FRUTOS, Rogelio, Perez; (US).
TAMPONE, Thomas, G.; (US).
MULDER, Jason, Alan; (US).
KRISHNAMURTHY, Dhileepkumar; (US).
SENANAYAKE, Chris, Hugh; (US)
Agent: MORRIS, Michael P.; (US)
Priority Data:
61/052,816 13.05.2008 US
Title (EN) SYNTHESIS OF DIHYDROTHIENO[3,2-d]PYRIMIDINE DIOLS AND SIMILAR PYRIMIDINE DIOLS
(FR) SYNTHÈSE DE DIOLS DIHYDROTHIÉNO[3,2-d]PYRIMIDINIQUES ET DE DIOLS PYRIMIDINIQUES ANALOGUES
Abstract: front page image
(EN)The present invention relates to an improved process for the preparation of dihydrothieno[3,2-d]pyrimidine diols, and similar pyrimidine diols, that is efficient, high-yielding, and does not require expensive and potentially unstable intermediates. The diols are used as intermediates in the synthesis of pyrimidine compounds which inhibit PDE4, and are thus useful in the treatment of respiratory or gastrointestinal diseases and complaints, peripheral or central nervous system diseases and disorders, inflammatory conditions, and cancers.
(FR)La présente invention concerne un procédé amélioré de préparation de diols dihydrothiénol[3,2-d]pyrimidiniques et de diols pyrimidiniques analogues. Ce procédé est efficace, présente un rendement élevé et ne requiert pas de produits intermédiaires coûteux et potentiellement instables. Les diols sont utilisés comme produits intermédiaires dans la synthèse de composés pyrimidiniques inhibant la PDE4, et sont donc utiles dans le traitement de maladies et de plaintes respiratoires ou gastro-intestinales, de maladies et de troubles du système nerveux central ou périphérique, d'affections inflammatoires et de cancers.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)