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1. (WO2009139925) METHODS FOR THE TREATMENT OF BRAIN EDEMA

Pub. No.:    WO/2009/139925    International Application No.:    PCT/US2009/003071
Publication Date: Nov 19, 2009 International Filing Date: May 18, 2009
IPC: A01N 47/34
A61K 31/175
Applicants: PANACEA PHARMACEUTICALS, INC.
JIANG, Zhi-Gang
Inventors: JIANG, Zhi-Gang
Title: METHODS FOR THE TREATMENT OF BRAIN EDEMA
Abstract:
The present invention is based on the discoveries that PAN-811 (1) reduces infarct volume, suppresses brain edema and decreases mortality associated with ischemia; (2) blocks veratridine-induced swelling and neuronal cell death; (3) chelates free calcium and inhibits MMP-9 activity; and (4) blocks calcium-induced neuronal cell death and suppresses glutamate- induced calcium influx into neuronal cells. More particularly, the present invention relates to methods for treating, ameliorating or preventing vasogenic and/or cytotoxic brain edema, by administering to a subject in need thereof certain thiosemicarbazone compounds or pharmaceutically acceptable salts thereof. An example of such a thiosemicarbazone is 3-aminopyridine-2-carboxaldehyde thiosemicarbazone (PAN-811).