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Machine translation
1. (WO2009139901) METHODS AND COMPOSITIONS FOR IMPROVING COGNITIVE FUNCTION
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2009/139901    International Application No.:    PCT/US2009/003030
Publication Date: 19.11.2009 International Filing Date: 14.05.2009
IPC:
A61K 31/19 (2006.01)
Applicants: THE JOHNS HOPKINS UNIVERSITY [US/US]; 3400 North Carles Street Ames Hall Baltimore, MD 21218 (US) (For All Designated States Except US).
GALLAGHER, Michela [US/US]; (US) (For US Only).
KOH, Ming, Teng [ID/US]; (US) (For US Only)
Inventors: GALLAGHER, Michela; (US).
KOH, Ming, Teng; (US)
Agent: HALEY, James, F., Jr.; Ropes & Gray LLP 1211 Avenue Of Americas New York, NY 10036 (US)
Priority Data:
61/127,534 14.05.2008 US
Title (EN) METHODS AND COMPOSITIONS FOR IMPROVING COGNITIVE FUNCTION
(FR) PROCÉDÉS ET COMPOSITIONS PERMETTANT L'AMÉLIORATION DE LA FONCTION COGNITIVE
Abstract: front page image
(EN)The invention relates to methods and compositions for improving cognitive function by using a combination of valproic acid and analogs and derivatives thereof ("valproate") and an acetylcholinesterase inhibitor (AChEI). In particular, it relates to the use of a combination of a valproate and an AChEI in treating age-related cognitive impairment in a subject in need or at risk thereof, including, without limitation, subjects having or at risk for Mild Cognitive Impairment (MCI), Age-Associated Memory Impairment (AAMI) or Age-Related Cognitive Decline (ARCD).
(FR)L'invention concerne des procédés et des compositions permettant l'amélioration de la fonction cognitive en utilisant une combinaison d'acides valproïques et d'analogues et dérivés de ces acides ("valproate") et d'un inhibiteur de l'acétylcholinestérase (AchEI). En particulier, elle concerne l'utilisation d'une combinaison d'un valproate et d'un AChEI dans le traitement d'un trouble cognitif lié à l'âge, chez un sujet en ayant besoin ou présentant un risque de trouble cognitif, y compris, sans caractère limitatif, les sujets atteints ou présentant un risque de trouble cognitif léger (MCI), de déficience de la mémoire liée à l'âge (AAMI) ou de déclin cognitif lié à l'âge (ARCD).
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)