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1. (WO2009139863) CHIMERIC SMALL MOLECULES FOR THE RECRUITMENT OF ANTIBODIES TO CANCER CELLS
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2009/139863    International Application No.:    PCT/US2009/002957
Publication Date: 19.11.2009 International Filing Date: 13.05.2009
IPC:
G01N 33/574 (2006.01)
Applicants: YALE UNIVERSITY [US/US]; Two Whitney Avenue New Haven, CT 06511 (US) (For All Designated States Except US).
SPIEGEL, David [US/US]; (US) (For US Only).
MURELLI, Ryan [US/US]; (US) (For US Only).
ZHANG, Andrew [US/US]; (US) (For US Only)
Inventors: SPIEGEL, David; (US).
MURELLI, Ryan; (US).
ZHANG, Andrew; (US)
Agent: COLEMAN, Henry, D.; (US)
Priority Data:
61/127,539 13.05.2008 US
Title (EN) CHIMERIC SMALL MOLECULES FOR THE RECRUITMENT OF ANTIBODIES TO CANCER CELLS
(FR) PETITES MOLÉCULES CHIMÉRIQUES POUR LE RECRUTEMENT D'ANTICORPS DIRIGÉS CONTRE DES CELLULES CANCÉREUSES
Abstract: front page image
(EN)The present invention relates to chimeric chemical compounds which are used to recruit antibodies to cancer cells, in particular, prostate cancer cells or metastasized prostate cancer cells. The compounds according to the present invention comprise an antibody binding terminus (ABT) moiety covalently bonded to a cell binding terminus(CBT) through a linker and optionally, a connector molecule.
(FR)La présente invention porte sur des composés chimiques chimériques qui sont utilisés pour recruter des anticorps dirigés contre des cellules cancéreuses, en particulier, des cellules cancéreuses de la prostate ou des cellules cancéreuses de la prostate métastasées. Les composés selon la présente invention comprennent une fraction à extrémité de liaison à un anticorps (ABT) liée de façon covalente à une extrémité de liaison à une cellule (CBT) par un liant et facultativement, une molécule de jonction.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)