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1. (WO2009139511) A COMPOSITION FOR REGULATION CELLULAR SENESCENCE COMPRISING LYSOPHOSPHATIDIC ACID AND INHIBITOR OF ADENYLYL CYCLASE AS ACTIVE INGREDIENTS
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2009/139511    International Application No.:    PCT/KR2008/002685
Publication Date: 19.11.2009 International Filing Date: 14.05.2008
IPC:
A61K 31/52 (2006.01), A61K 8/64 (2006.01), C12Q 1/00 (2006.01)
Applicants: SEOUL NATIONAL UNIVERSITY INDUSTRY FOUNDATION [KR/KR]; San 4-2 Bongcheon-dong, Gwanak-gu Seoul 151-818 (KR) (For All Designated States Except US).
PARK, Sang Chul [KR/KR]; (KR) (For US Only).
YEO, Eui Ju [KR/KR]; (KR) (For US Only).
RHIM, Ji Heon [KR/KR]; (KR) (For US Only)
Inventors: PARK, Sang Chul; (KR).
YEO, Eui Ju; (KR).
RHIM, Ji Heon; (KR)
Agent: SESHIN PATENT & LAW FIRM; #207, World Meridian Venture Center II, 426-5, Gasan-dong, Geumcheon-gu, Seoul 153-781 (KR)
Priority Data:
Title (EN) A COMPOSITION FOR REGULATION CELLULAR SENESCENCE COMPRISING LYSOPHOSPHATIDIC ACID AND INHIBITOR OF ADENYLYL CYCLASE AS ACTIVE INGREDIENTS
(FR) COMPOSITION DESTINÉE À LA RÉGULATION DE LA SÉNESCENCE CELLULAIRE RENFERMANT DE L’ACIDE LYSOPHOSPHATIDIQUE ET UN INHIBITEUR DE L’ADÉNYL-CYCLASE EN TANT QUE PRINCIPES ACTIFS
Abstract: front page image
(EN)The present invention relates to the molecular mechanism inducing cell proliferation in aged human fibroblasts by inhibiting AMPK using LPA and AC inhibitor. Particularly, the present invention relates to a composition comprising LPA and ACI as active ingredients and the invention proves with the said composition that LPA and ACI regulate different phosphorylation of AMPK α and thus inactivate p53 and induce senescent cell proliferation. This results support the fact that AMPK signal transduction plays an important role in cell proliferation of senescent cells.
(FR)La présente invention concerne le mécanisme moléculaire induisant la prolifération cellulaire de fibroblastes humains âgés par l’inhibition de l’AMPK à l’aide de LPA et d’un inhibiteur de l’AC. De manière particulière, la présente invention concerne une composition renfermant du LPA et un ACI en tant que principes actifs et l’invention prouve avec ladite composition que le LPA et l’ACI régulent une phosphorylation différente de l’AMPK α et ainsi inactivent p53 et induisent une prolifération des cellules sénescentes. Ce résultat supporte le fait que la transduction des signaux de l’AMPK joue un rôle important dans la prolifération cellulaire des cellules sénescentes.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, SV, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MT, NL, NO, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: Korean (KO)