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Pub. No.:    WO/2009/139411    International Application No.:    PCT/JP2009/058913
Publication Date: 19.11.2009 International Filing Date: 13.05.2009
A61K 31/439 (2006.01), A61K 9/70 (2006.01), A61K 47/10 (2006.01), A61K 47/32 (2006.01)
Applicants: HISAMITSU PHARMACEUTICAL CO., INC. [JP/JP]; 408, Tashirodaikan-machi, Tosu-shi, Saga 8410017 (JP) (For All Designated States Except US).
YASUKOCHI Takashi [JP/JP]; (JP) (For US Only).
NAKA Yukihisa [JP/JP]; (JP) (For US Only).
ENDO Tsuyoshi [JP/JP]; (JP) (For US Only).
ADACHI Hirotoshi [JP/US]; (US) (For US Only)
Inventors: YASUKOCHI Takashi; (JP).
NAKA Yukihisa; (JP).
ENDO Tsuyoshi; (JP).
ADACHI Hirotoshi; (US)
Agent: HASEGAWA Yoshiki; SOEI PATENT AND LAW FIRM, Marunouchi MY PLAZA (Meiji Yasuda Life Bldg.) 9th fl., 1-1, Marunouchi 2-chome, Chiyoda-ku, Tokyo 1000005 (JP)
Priority Data:
61/071,740 15.05.2008 US
(JA) パロノセトロンを含有する経皮吸収製剤
Abstract: front page image
(EN)Disclosed is a transdermal preparation comprising a supporting body and a drug-containing pressure-sensitive adhesive layer arranged on at least one side of the supporting body. The drug-containing pressure-sensitive adhesive layer is composed of components essentially including an adhesive base agent, palonosetron or a pharmaceutically acceptable acid addition salt thereof, and at least one aliphatic alcohol selected from the group consisting of linear saturated alcohols having 6-12 carbon atoms, linear unsaturated alcohols having 10-22 carbon atoms, branched alcohols having 10-22 carbon atoms and cyclic alcohols having 10-15 carbon atoms. The components other than palonosetron or a pharmaceutically acceptable acid addition salt thereof do not contain a carboxyl group.
(FR)La présente invention concerne une préparation transdermique comprenant un corps de support et une couche adhésive autocollante contenant un médicament agencée sur au moins une face du corps de support. La couche adhésive autocollante contenant un médicament est composée de composants comprenant essentiellement un agent de base adhésif, de la palonosétrone ou un sel d'addition acide pharmaceutiquement acceptable de celle-ci, et au moins un alcool aliphatique choisi dans le groupe constitué d'alcools saturés linéaires ayant de 6 à 12 atomes de carbone, d'alcools insaturés linéaires ayant de 10 à 22 atomes de carbone, d'alcools ramifiés ayant de 10 à 22 atomes de carbone et d'alcools cycliques ayant de 10 à 15 atomes de carbone. Les composants autres que la palonosétrone ou un sel d'addition acide pharmaceutiquement acceptable de celle-ci ne contiennent pas un groupe carboxyle.
(JA) 支持体と、該支持体の少なくとも一方面上に設けられた薬物含有感圧接着剤層とを備える経皮吸収製剤であって、薬物含有感圧接着剤層は、粘着基剤と、パロノセトロン又はその薬学的に許容される酸付加塩と、炭素数6~12の直鎖飽和アルコール、炭素数10~22の直鎖不飽和アルコール、炭素数10~22の分岐アルコール及び炭素数10~15の環状アルコールからなる群より選択される少なくとも1種の脂肪族アルコールと、を必須とする構成成分からなり、パロノセトロン又はその薬学的に許容される酸付加塩以外の構成成分は、カルボキシル基を有しない成分である、経皮吸収製剤。
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: Japanese (JA)
Filing Language: Japanese (JA)