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1. (WO2009139373) AMIDE COMPOUND
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2009/139373    International Application No.:    PCT/JP2009/058821
Publication Date: 19.11.2009 International Filing Date: 12.05.2009
IPC:
C07C 233/47 (2006.01), A61K 31/166 (2006.01), A61K 31/195 (2006.01), A61K 31/381 (2006.01), A61K 31/40 (2006.01), A61K 31/404 (2006.01), A61K 31/407 (2006.01), A61K 31/415 (2006.01), A61K 31/416 (2006.01), A61K 31/4184 (2006.01), A61K 31/422 (2006.01), A61K 31/423 (2006.01), A61K 31/427 (2006.01), A61K 31/428 (2006.01), A61K 31/437 (2006.01), A61K 31/44 (2006.01), A61K 31/4412 (2006.01), A61K 31/4439 (2006.01), A61K 31/454 (2006.01), A61K 31/4545 (2006.01), A61K 31/47 (2006.01), A61K 31/4709 (2006.01), A61K 31/4725 (2006.01), A61P 1/04 (2006.01), A61P 7/10 (2006.01), A61P 9/10 (2006.01), A61P 9/12 (2006.01), A61P 13/02 (2006.01), A61P 13/04 (2006.01), A61P 13/12 (2006.01), A61P 17/02 (2006.01), A61P 29/00 (2006.01), A61P 35/00 (2006.01), A61P 35/04 (2006.01), A61P 43/00 (2006.01), C07C 251/38 (2006.01), C07C 271/22 (2006.01), C07D 207/34 (2006.01), C07D 209/08 (2006.01), C07D 213/79 (2006.01), C07D 215/14 (2006.01), C07D 217/04 (2006.01), C07D 231/56 (2006.01), C07D 235/12 (2006.01), C07D 263/58 (2006.01), C07D 333/40 (2006.01), C07D 401/06 (2006.01), C07D 401/12 (2006.01), C07D 403/12 (2006.01), C07D 405/06 (2006.01), C07D 409/06 (2006.01), C07D 409/14 (2006.01), C07D 413/06 (2006.01), C07D 417/06 (2006.01), C07D 417/10 (2006.01), C07D 471/04 (2006.01), C07D 491/04 (2006.01), C07D 491/048 (2006.01), C07D 495/04 (2006.01)
Applicants: ASTELLAS PHARMA INC. [JP/JP]; 3-11, Nihonbashi-Honcho 2-chome, Chuo-ku Tokyo 1038411 (JP) (For All Designated States Except US).
NOZAWA, Eisuke [JP/JP]; (JP) (For US Only).
IBUKA, Ryotaro [JP/JP]; (JP) (For US Only).
IKEGAI, Kazuhiro [JP/JP]; (JP) (For US Only).
MATSUURA, Keisuke [JP/JP]; (JP) (For US Only).
ZENKOH, Tatsuya [JP/JP]; (JP) (For US Only).
SEO, Ryushi [JP/JP]; (JP) (For US Only).
WATANUKI, Susumu [JP/JP]; (JP) (For US Only).
KAGEYAMA, Michihito [JP/JP]; (JP) (For US Only)
Inventors: NOZAWA, Eisuke; (JP).
IBUKA, Ryotaro; (JP).
IKEGAI, Kazuhiro; (JP).
MATSUURA, Keisuke; (JP).
ZENKOH, Tatsuya; (JP).
SEO, Ryushi; (JP).
WATANUKI, Susumu; (JP).
KAGEYAMA, Michihito; (JP)
Agent: MORITA, Hiroshi; (JP)
Priority Data:
2008-127424 14.05.2008 JP
Title (EN) AMIDE COMPOUND
(FR) COMPOSÉ AMIDE
(JA) アミド化合物
Abstract: front page image
(EN)Disclosed is a compound useful as an active ingredient of a pharmaceutical composition, such as a pharmaceutical composition for treating chronic renal failure and/or diabetic nephropathy. Extensive studies are made for the purpose of finding a compound having an antagonistic activity on an EP4 receptor, and it is confirmed that a specific amide compound has an antagonistic activity on an EP4 receptor.  The amide compound has an antagonistic activity on an EP4 receptor, and therefore can be used as an active ingredient of a pharmaceutical composition for preventing and/or treating various diseases associated with EP4, such as chronic renal failure and/or diabetic nephropathy.
(FR)La présente invention concerne un composé utile en tant que principe actif d’une composition pharmaceutique, telle qu’une composition pharmaceutique destinée au traitement de l’insuffisance rénale chronique et/ou de la néphropathie diabétique. Des études approfondies sont réalisées en vue de découvrir un composé ayant une activité antagoniste sur un récepteur EP4, et confirment qu’un composé amide spécifique a une activité antagoniste sur un récepteur EP4. Le composé amide a une activité antagoniste sur un récepteur EP4, et peut par conséquent être utilisé en tant que principe actif d’une composition pharmaceutique destinée à prévenir et/ou traiter différentes maladies associées à EP4, telles que l’insuffisance rénale chronique et/ou la néphropathie diabétique.
(JA)【課題】医薬組成物、例えば慢性腎不全、及び/又は糖尿病性腎症の治療用医薬組成物の有効成分として有用な化合物を提供する。 【解決手段】本発明者らは、EP4受容体拮抗作用を有する化合物について鋭意検討し、本発明のアミド化合物がEP4受容体拮抗作用を有することを確認し、本発明を完成した。本発明のアミド化合物は、EP4受容体拮抗作用を有し、EP4が関与する種々の疾患、例えば、慢性腎不全、及び/又は糖尿病性腎症等の予防及び/又は治療用医薬組成物の有効成分として使用しうる。
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: Japanese (JA)
Filing Language: Japanese (JA)