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1. (WO2009138877) HETEROLOGOUS EXPRESSION OF FUNGAL CELLOBIOHYDROLASES IN YEAST
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2009/138877    International Application No.:    PCT/IB2009/005881
Publication Date: 19.11.2009 International Filing Date: 11.05.2009
IPC:
C12N 9/42 (2006.01), C12P 7/10 (2006.01), C12N 15/56 (2006.01)
Applicants: UNIVERSITEIT STELLENBOSCH [ZA/ZA]; Private Bag X1 Matieland 7602 Stellenbosch (ZA) (For All Designated States Except US).
DEN HAAN, Riaan [ZA/ZA]; (ZA) (For US Only).
VAN ZYL, Emile [ZA/ZA]; (ZA) (For US Only).
LAGRANGE, Danie [ZA/ZA]; (ZA) (For US Only)
Inventors: DEN HAAN, Riaan; (ZA).
VAN ZYL, Emile; (ZA).
LAGRANGE, Danie; (ZA)
Priority Data:
61/052,213 11.05.2008 US
Title (EN) HETEROLOGOUS EXPRESSION OF FUNGAL CELLOBIOHYDROLASES IN YEAST
(FR) EXPRESSION HÉTÉROLOGUE DE CELLOBIOHYDROLASES FONGIQUES DANS LA LEVURE
Abstract: front page image
(EN)The present invention provides for heterologous expression of polypeptides encoded by wild-type and codon-optimized variants of cbhl and/or cbh2 from the fungal organisms Talaromyces emersonii (T. emersonii), Humicola grisea (H. grisea), Thermoascus aurantiacus (T. aurantiacus), and Trichoderma reesei (T. reesei) in host cells, such as the yeast Saccharomyces cerevisiae. The expression in such host cells of the corresponding genes, and variants and combinations thereof, result in improved specific activity of the expressed cellobiohydrolases. Thus, such genes and expression systems are useful for efficient and cost- effective consolidated bioprocessing systems.
(FR)L'invention concerne l'expression hétérologue de polypeptides codés par des variants de type sauvage et optimisés par codon de cbhl et/ou cbh2 provenant d'organismes fongiques Talaromyces emersonii (T. emersonii), Humicola grisea (H. grisea), Thermoascus aurantiacus (T. aurantiacus), et Trichoderma reesei (T. reesei), dans des cellules hôtes telles que la levure Saccharomyces cerevisiae. L'expression des gènes correspondants, des variants et de leurs combinaisons, dans de telles cellules hôtes, se traduit par une activité spécifique améliorée des cellobiohydrolases exprimées. Ainsi, de tel gènes et systèmes d'expression sont utiles pour des systèmes de bio-traitement consolidés, efficaces et économiques.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)