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1. WO2009138788 - SUBSTITUTED QUINAZOLINES

Publication Number WO/2009/138788
Publication Date 19.11.2009
International Application No. PCT/GB2009/050508
International Filing Date 13.05.2009
Chapter 2 Demand Filed 12.02.2010
IPC
C07D 239/84 2006.1
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
239Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
70condensed with carbocyclic rings or ring systems
72Quinazolines; Hydrogenated quinazolines
78with hetero atoms directly attached in position 2
84Nitrogen atoms
A61K 31/517 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
395having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
495having six-membered rings with two nitrogen atoms as the only ring hetero atoms, e.g. piperazine
505Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
517ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
A61P 7/02 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
7Drugs for disorders of the blood or the extracellular fluid
02Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
CPC
A61P 7/02
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
7Drugs for disorders of the blood or the extracellular fluid
02Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
C07D 239/84
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
239Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
70condensed with carbocyclic rings or ring systems
72Quinazolines; Hydrogenated quinazolines
78with hetero atoms directly attached in position 2
84Nitrogen atoms
Applicants
  • SHIRE LLC [US]/[US] (AllExceptUS)
  • GOLDING, Bernard [GB]/[GB] (UsOnly)
  • CICALA, Peter [US]/[US] (UsOnly)
  • FRANKLIN, Richard [GB]/[GB] (UsOnly)
  • MACLEOD, Angus [GB]/[GB] (UsOnly)
Inventors
  • GOLDING, Bernard
  • CICALA, Peter
  • FRANKLIN, Richard
  • MACLEOD, Angus
Agents
  • HARRISON GODDARD FOOTE
Priority Data
0808948.416.05.2008GB
Publication Language English (en)
Filing Language English (EN)
Designated States
Title
(EN) SUBSTITUTED QUINAZOLINES
(FR) QUINAZOLINES SUBSTITUÉES
Abstract
(EN) This invention relates to the discovery of prodrugs of substituted analogues of the selective platelet lowering agent anagrelide which have reduced potential for cardiovascular side-effects and which should therefore lead to improved patient compliance and safety in the treatment of myeloproliferative diseases. More specifically, the present invention relates to prodrugs of certain imidazoquinazoline derivatives which have the general formula (I) shown below wherein the substituents have the meanings defined in claim 1 and which have utility as platelet lowering agents in humans. The compounds of the present invention function by inhibiting the formation of blood platelets.
(FR) L'invention concerne la découverte de promédicaments d'analogues substitués de l'anagrélide, un agent de réduction sélective du nombre des plaquettes, qui présentent un potentiel réduit d'effets secondaires cardiovasculaires et qui, par conséquent, devraient conduire à une observance thérapeutique et à une sécurité améliorées dans le traitement de syndromes myéloprolifératifs. Plus spécifiquement, la présente invention concerne des promédicaments de certains dérivés d'imidazoquinazoline représentés par la formule générale (I) ci-dessous, dans laquelle les substituants ont les significations définies dans la revendication 1 et qui présentent une utilité en tant qu'agents de réduction du nombre des plaquettes chez les êtres humains. Les composés de la présente invention agissent en inhibant la formation des plaquettes sanguines.
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