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1. (WO2009138788) SUBSTITUTED QUINAZOLINES
Latest bibliographic data on file with the International Bureau   

Pub. No.: WO/2009/138788 International Application No.: PCT/GB2009/050508
Publication Date: 19.11.2009 International Filing Date: 13.05.2009
Chapter 2 Demand Filed: 12.02.2010
IPC:
C07D 239/84 (2006.01) ,A61K 31/517 (2006.01) ,A61P 7/02 (2006.01)
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
239
Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
70
condensed with carbocyclic rings or ring systems
72
Quinazolines; Hydrogenated quinazolines
78
with hetero atoms directly attached in position 2
84
Nitrogen atoms
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
395
having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
495
having six-membered rings with two nitrogen atoms as the only ring hetero atoms, e.g. piperazine
505
Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
517
ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
7
Drugs for disorders of the blood or the extracellular fluid
02
Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
Applicants:
GOLDING, Bernard [GB/GB]; GB (UsOnly)
CICALA, Peter [US/US]; US (UsOnly)
FRANKLIN, Richard [GB/GB]; GB (UsOnly)
MACLEOD, Angus [GB/GB]; GB (UsOnly)
SHIRE LLC [US/US]; 9200 Brookfield Court Florence, Kentucky 41042, US (AllExceptUS)
Inventors:
GOLDING, Bernard; GB
CICALA, Peter; US
FRANKLIN, Richard; GB
MACLEOD, Angus; GB
Agent:
HARRISON GODDARD FOOTE; Belgrave Hall Belgrave Street Leeds West Yorkshire LS2 8DD, GB
Priority Data:
0808948.416.05.2008GB
Title (EN) SUBSTITUTED QUINAZOLINES
(FR) QUINAZOLINES SUBSTITUÉES
Abstract:
(EN) This invention relates to the discovery of prodrugs of substituted analogues of the selective platelet lowering agent anagrelide which have reduced potential for cardiovascular side-effects and which should therefore lead to improved patient compliance and safety in the treatment of myeloproliferative diseases. More specifically, the present invention relates to prodrugs of certain imidazoquinazoline derivatives which have the general formula (I) shown below wherein the substituents have the meanings defined in claim 1 and which have utility as platelet lowering agents in humans. The compounds of the present invention function by inhibiting the formation of blood platelets.
(FR) L'invention concerne la découverte de promédicaments d'analogues substitués de l'anagrélide, un agent de réduction sélective du nombre des plaquettes, qui présentent un potentiel réduit d'effets secondaires cardiovasculaires et qui, par conséquent, devraient conduire à une observance thérapeutique et à une sécurité améliorées dans le traitement de syndromes myéloprolifératifs. Plus spécifiquement, la présente invention concerne des promédicaments de certains dérivés d'imidazoquinazoline représentés par la formule générale (I) ci-dessous, dans laquelle les substituants ont les significations définies dans la revendication 1 et qui présentent une utilité en tant qu'agents de réduction du nombre des plaquettes chez les êtres humains. Les composés de la présente invention agissent en inhibant la formation des plaquettes sanguines.
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Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (EPO) (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)