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1. (WO2009138779) COMBINATION COMPRISING 4- (3-CHLORO-2-FLUOROANILINO) -7-METH0XY-6- { [1- (N-METHYLCARBAMOYLMETHYL) PIPERIDIN- 4-YL] OXYJQUINAZOLINE
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2009/138779    International Application No.:    PCT/GB2009/050494
Publication Date: 19.11.2009 International Filing Date: 11.05.2009
IPC:
A61K 31/517 (2006.01), A61P 35/00 (2006.01)
Applicants: ASTRAZENECA AB [SE/SE]; S-151 85 Södertälje (SE) (AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BE, BF, BG, BH, BJ, BR, BW, BY, BZ, CA, CF, CG, CH, CI, CM, CN, CO, CR, CU, CY, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, FR, GA, GB, GD, GE, GH, GM, GN, GQ, GR, GT, GW, HN, HR, HU, ID, IE, IL, IN, IS, IT, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LV, LY, MA, MC, MD, ME, MK, ML, MN, MR, MT, MW, MX, MY, MZ, NA, NE, NG, NI, NL, NO, NZ, OM, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SI, SK, SL, SM, SN, ST, SV, SY, SZ, TD, TG, TJ, TM, TN, TR, TT, TZ, UA, UG, UZ, VC, VN, ZA, ZM, ZW only).
ASTRAZENECA UK LIMITED [GB/GB]; 15 Stanhope Gate London Greater London W1K 1LN (GB) (MG only).
IACONA, Lisa, Renee, Bailey [US/US]; (US) (For US Only).
SMITH, Ian [GB/GB]; (GB) (For US Only).
STUART, Mary [IE/GB]; (GB) (For US Only)
Inventors: IACONA, Lisa, Renee, Bailey; (US).
SMITH, Ian; (GB).
STUART, Mary; (GB)
Agent: ASTRAZENECA INTELLECTUAL PROPERTY; AstraZeneca AB S-151 85 Södertälje (SE)
Priority Data:
61/052,706 13.05.2008 US
61/110,664 03.11.2008 US
61/120,583 08.12.2008 US
Title (EN) COMBINATION COMPRISING 4- (3-CHLORO-2-FLUOROANILINO) -7-METH0XY-6- { [1- (N-METHYLCARBAMOYLMETHYL) PIPERIDIN- 4-YL] OXYJQUINAZOLINE
(FR) COMBINAISON COMPRENANT DE LA 4-(3-CHLORO-2-FLUOROANILINO)-7-MÉTHOXY-6-{[1-(N-MÉTHYLCARBAMOYLMÉTHYL)PIPÉRIDIN-4-YL]OXY}QUINAZOLINE
Abstract: front page image
(EN)A combination, comprising 4-(3-chloro-2-fluoroanilino)-7-methoxy-6-{[l-(N- methylcarbamoylmethyl)piperidin-4-yl ]oxy}quinazoline, or a pharmaceutically acceptable salt thereof, and an endocrine agent suitable for use in the treatment of breast cancer is described. Also described is the use of the combination in the treatment of cancer.
(FR)L'invention porte sur une combinaison comprenant de la 4-(3-chloro-2-fluoroanilino)-7-méthoxy-6-{[1-(N-méthylcarbamoylméthyl)pipéridin-4-yl]oxy}quinazoline, ou sur un sel pharmaceutiquement acceptable de celle-ci, et sur un agent endocrinien approprié pour une utilisation dans le traitement du cancer du sein. L'invention porte également sur l'utilisation de la combinaison dans le traitement du cancer.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)