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1. WO2009138707 - QUINUCLIDINE DERIVATIVES AS MUSCARINIC M3 RECEPTOR ANTAGONISTS

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Publication Number WO/2009/138707
Publication Date 19.11.2009
International Application No. PCT/GB2008/001647
International Filing Date 13.05.2008
IPC
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
453
Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids
02
containing not further condensed quinuclidine ring systems
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
395
having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
435
having six-membered rings with one nitrogen as the only ring hetero atom
439
the ring forming part of a bridged ring system, e.g. quinuclidine
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
11
Drugs for disorders of the respiratory system
C07D 453/02 (2006.01)
A61K 31/439 (2006.01)
A61P 11/00 (2006.01)
CPC
C07D 453/02
Applicants
  • ASTRAZENECA AB [SE/SE]; S-151 85 Sodertalje, SE (AllExceptUS)
  • PULMAGEN THERAPEUTICS (SYNERGY) LIMITED [GB/GB]; Fulmer Hall Windmill Road Fulmer Slough SL3 6HD, GB (AllExceptUS)
  • FORD, Rhonan, Lee [GB/GB]; GB (UsOnly)
  • MATHER, Andrew, Nigel [GB/GB]; GB (UsOnly)
  • METE, Antonio [IT/GB]; GB (UsOnly)
  • BULL, Richard, James [GB/GB]; GB (UsOnly)
  • SKIDMORE, Elizabeth, Anne [GB/GB]; GB (UsOnly)
Inventors
  • FORD, Rhonan, Lee; GB
  • MATHER, Andrew, Nigel; GB
  • METE, Antonio; GB
  • BULL, Richard, James; GB
  • SKIDMORE, Elizabeth, Anne; GB
Agents
  • STANSFIELD, Kevin; AstraZeneca AB Global Intellectual Property SE-151 85 Södertälje, SE
Priority Data
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) QUINUCLIDINE DERIVATIVES AS MUSCARINIC M3 RECEPTOR ANTAGONISTS
(FR) DÉRIVÉS DE QUINUCLIDINE UTILISÉS COMME ANTAGONISTES DES RÉCEPTEURS MUSCARINIQUES M3
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Abstract
(EN)
The invention provides named compounds of formula (I), wherein R4 is a N- sustituted quinuclidine (I) pharmaceutical compositions containing them and a process for preparing the pharmaceutical compositions. Their use in therapy for' the treatment of conditions mediated by M3 muscarinic receptors, such as chronic obstructive pulmonary disease is also disclosed.
(FR)
L'invention porte sur des composés représentés par la formule (I), dans laquelle R4 est une quinuclidine substituée en N (I), sur des compositions pharmaceutiques les contenant et sur un procédé de fabrication de ces compositions pharmaceutiques. L'invention porte également sur leur utilisation en thérapie pour le traitement d'affections à médiation par les récepteurs muscariniques M3, telles qu'une bronchopneumopathie chronique obstructive.
Also published as
AU2008356409
BRPI0822693
CA2723981
CN102089304
CO10137232
CR201011790
CRCR2010-011790
CUD2010217
DOP2010000347
EA201001645
EG2010111843
EP2300464
ID051.2699
IL209126
IN2373/MUMNP/2010
JP2011520853
MXMX/a/2010/012189
MYPI 2010005265
NZ589091
PH12010502552
SG166329
UAa201013072
US20110172237
VN1201003166
VN27309
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