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1. (WO2009138542) USE OF HSP90 PROTEIN INHIBITING COMPOUNDS AND PHARMACEUTICAL COMPOSITION INTENDED FOR ANTI-TUMOUR THERAPY
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2009/138542    International Application No.:    PCT/ES2009/070152
Publication Date: 19.11.2009 International Filing Date: 11.05.2009
IPC:
A61K 35/00 (2006.01), C07D 225/06 (2006.01), A61P 35/00 (2006.01)
Applicants: CONSEJO SUPERIOR DE INVESTIGACIONES CIENTÍFICAS [ES/ES]; C/ Serrano, 117 E-28006 Madrid (ES) (For All Designated States Except US).
UNIVERSIDAD DE SALAMANCA [ES/ES]; Patio de Escuelas, 1 E-37008 Salamanca (ES) (For All Designated States Except US).
DE ALAVA CASADO, Enrique [ES/ES]; (ES) (For US Only).
DA SILVA MARTINS, Ana Sofia [PT/ES]; (ES) (For US Only)
Inventors: DE ALAVA CASADO, Enrique; (ES).
DA SILVA MARTINS, Ana Sofia; (ES)
Agent: PONS ARIÑO, Ángel; (ES)
Priority Data:
P200801371 13.05.2008 ES
Title (EN) USE OF HSP90 PROTEIN INHIBITING COMPOUNDS AND PHARMACEUTICAL COMPOSITION INTENDED FOR ANTI-TUMOUR THERAPY
(ES) USO DE COMPUESTOS INHIBIDORES DE LA PROTEÍNA HSP90 Y COMPOSICIÓN FARMACÉUTICA DESTINADA A TERAPIA ANTITUMORAL
(FR) UTILISATION DE COMPOSÉS INHIBITEURS DE LA PROTÉINE HSP90 ET COMPOSITION PHARMACEUTIQUE DESTINÉE AU TRAITEMENT ANTITUMORAL
Abstract: front page image
(EN)The invention relates to a method for designing an individual anti-tumour therapy for a patient based on the detection of the levels of the Hsp90 protein responsible for resistance to a drug or a mixture of anti-tumour drugs that inhibit receptors IGF1R/KIT. The invention also relates to the use of Hsp90 protein inhibitors for the production of drugs for the treatment of tumours resistant to IGF1R/KIT inhibitors, the resulting pharmaceutical compositions and the use thereof on Ewing's sarcoma tumours.
(ES)La presente invención describe un procedimiento para diseñar una terapia individual antitumoral a un sujeto basado en la detección de los niveles de proteína HSP90 responsable de la resistencia a un medicamento o a una mezcla de medicamentos antitumorales inhibidores de los receptores IGF1R/KIT. Igualmente, describe el uso de inhibidores de la proteína HSP90 para la elaboración de medicamentos para el tratamiento de tumores resistentes a los inhibidores de IGF1R/KIT, las composiciones farmacéuticas así obtenidas y sus aplicaciones en tumores como el sarcoma de Ewing.
(FR)L'invention concerne un procédé destiné à concevoir un traitement antitumoral individuel à un sujet fondé sur la détection des niveaux de protéine HSP90 responsables de la résistance à un médicament ou à un mélange de médicaments antitumoraux inhibiteurs des récepteurs IGF1R/KIT. Elle concerne également l'utilisation d'inhibiteurs de la protéine HSP90 destinée à élaborer des médicaments pour le traitement de tumeurs résistantes aux inhibiteurs IGF1R/KIT. Elle concerne enfin les compositions pharmaceutiques ainsi obtenues et leurs applications sur des tumeurs comme le sarcome d'Ewing.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: Spanish (ES)
Filing Language: Spanish (ES)