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Machine translation
1. (WO2009138472) AMPHIPHILIC BLOCK COPOLYMERS FOR NUCLEIC ACID DELIVERY
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2009/138472    International Application No.:    PCT/EP2009/055864
Publication Date: 19.11.2009 International Filing Date: 14.05.2009
IPC:
A61K 47/48 (2006.01)
Applicants: Biocompatibles UK Limited [GB/GB]; Chapman House Farnham Business Park Weydon Lane Farnham Surrey GU9 8QL (GB) (For All Designated States Except US).
LEWIS, Andrew, Lennard [GB/GB]; (GB) (For US Only).
BATTAGLIA, Giuseppe [IT/GB]; (GB) (For US Only).
CANTON, Irene [ES/GB]; (GB) (For US Only).
STRATFORD, Peter, William [GB/GB]; (GB) (For US Only)
Inventors: LEWIS, Andrew, Lennard; (GB).
BATTAGLIA, Giuseppe; (GB).
CANTON, Irene; (GB).
STRATFORD, Peter, William; (GB)
Agent: JONES, Helen, Marjorie, Meredith; (GB)
Priority Data:
08156272.0 15.05.2008 EP
Title (EN) AMPHIPHILIC BLOCK COPOLYMERS FOR NUCLEIC ACID DELIVERY
(FR) COPOLYMÈRES BLOC AMPHIPHILES PERMETTANT LA LIBÉRATION D'ACIDES NUCLÉIQUES
Abstract: front page image
(EN)The present invention provides a composition comprising vesicles and encapsulated within the vesicles, nucleic acid comprising less than 1000 nucleotides, wherein the vesicles comprise an amphiphilic block copolymer having a hydrophilic and a hydrophobic block. Methods of forming vesicles and methods of delivering nucleic acid, in particular, iRNA into cells, are also provided.
(FR)La présente invention concerne une composition comprenant des vésicules à l'intérieur desquelles est encapsulé un acide nucléique comprenant moins de 1000 nucléotides. Les vésicules comprennent un copolymère bloc amphiphile présentant un bloc hydrophile et un bloc hydrophobe. L'invention concerne également des procédés permettant de former des vésicules et des procédés permettant de libérer un acide nucléique, en particulier, un ARNi dans des cellules.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)