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Machine translation
1. (WO2009138378) 3,5-DIAMINO-6-CHLORO-PYRAZINE-2-CARBOXYLIC ACID DERIVATIVES AND THEIR USE AS EPITHELIAL SODIUM CHANNEL BLOCKERS FOR THE TREATMENT OF ARWAY DISEASES
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2009/138378    International Application No.:    PCT/EP2009/055657
Publication Date: 19.11.2009 International Filing Date: 11.05.2009
IPC:
C07D 241/28 (2006.01), C07D 403/12 (2006.01), A61K 31/497 (2006.01), A61P 11/00 (2006.01)
Applicants: NOVARTIS AG [CH/CH]; Lichtstrasse 35 CH-4056 Basel (CH) (For All Designated States Except US).
COLLINGWOOD, Stephen Paul [GB/GB]; (GB) (For US Only).
HOWSHAM, Catherine [GB/GB]; (GB) (For US Only).
HUNT, Thomas Anthony [GB/GB]; (GB) (For US Only)
Inventors: COLLINGWOOD, Stephen Paul; (GB).
HOWSHAM, Catherine; (GB).
HUNT, Thomas Anthony; (GB)
Agent: VOEGELI-LANGE, Regina; (CH)
Priority Data:
08156060.9 13.05.2008 EP
Title (EN) 3,5-DIAMINO-6-CHLORO-PYRAZINE-2-CARBOXYLIC ACID DERIVATIVES AND THEIR USE AS EPITHELIAL SODIUM CHANNEL BLOCKERS FOR THE TREATMENT OF ARWAY DISEASES
(FR) DÉRIVÉS D'ACIDE 3,5-DIAMINO-6-CHLOROPYRAZINE-2-CARBOXYLIQUE ET LEUR UTILISATION COMME BLOQUEUR DU CANAL SODIQUE ÉPITHÉLIAL POUR LE TRAITEMENT DE MALADIES DES VOIES AÉRIENNES
Abstract: front page image
(EN)A compound of Formula (I) in free or salt or solvate form, where R1, R2, R3, R4, R5, R6, R7, R8 and R9 have the meanings as indicated in the specification, is useful for treating diseases which respond to the blockade of the epithelial sodium channel. Pharmaceutical compositions that contain the compounds and processes for preparing the compounds are also described.
(FR)L'invention porte sur un composé de Formule (I) sous forme libre ou de sel ou de solvate, dans laquelle formule R1, R2, R3, R4, R5, R6, R7, R8 et R9 ont les significations telles qu'indiquées dans la description, lequel composé est utile pour le traitement de maladies qui sont sensibles au blocage du canal sodique épithélial. L'invention porte également sur des compositions pharmaceutiques qui contiennent les composés et sur des procédés pour la fabrication des composés.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)