WIPO logo
Mobile | Deutsch | Español | Français | 日本語 | 한국어 | Português | Русский | 中文 | العربية |
PATENTSCOPE

Search International and National Patent Collections
World Intellectual Property Organization
Search
 
Browse
 
Translate
 
Options
 
News
 
Login
 
Help
 
Machine translation
1. (WO2009138235) PROCESS FOR THE PREPARATION OF O-DESMETHYLVENLAFAXINE SALTS
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2009/138235    International Application No.:    PCT/EP2009/003445
Publication Date: 19.11.2009 International Filing Date: 14.05.2009
IPC:
C07C 213/08 (2006.01), C07C 215/64 (2006.01), C07B 41/10 (2006.01)
Applicants: KRKA, TOVARNA ZDRAVIL, D.D., NOVO MESTO [SI/SI]; Smarjeska cesta 6 8501 Novo Mesto (SI) (For All Designated States Except US).
ZUPANCIC, Silvo [SI/SI]; (SI) (For US Only).
VRECER, Franc [SI/SI]; (SI) (For US Only).
SKRABANJA, Vida [SI/SI]; (SI) (For US Only).
HVALEC, Miran [SI/SI]; (SI) (For US Only).
SMRKOLJ, Matej [SI/SI]; (SI) (For US Only).
GERMAN, Tamara [SI/SI]; (SI) (For US Only)
Inventors: ZUPANCIC, Silvo; (SI).
VRECER, Franc; (SI).
SKRABANJA, Vida; (SI).
HVALEC, Miran; (SI).
SMRKOLJ, Matej; (SI).
GERMAN, Tamara; (SI)
Agent: NOHLEN, Martin; Uexküll & Stolberg, Beselerstr. 4, 22607 Hamburg (DE)
Priority Data:
08009047.5 16.05.2008 EP
Title (EN) PROCESS FOR THE PREPARATION OF O-DESMETHYLVENLAFAXINE SALTS
(FR) PROCÉDÉ DE PRÉPARATION DE SELS DE O-DESMÉTHYLVENLAFAXINE
Abstract: front page image
(EN)The present invention relates to a process for the preparation of a salt of O-desmethylvenlafaxine comprising a) dissolving or suspending O-desmethylvenlafaxine in the form of its base in a liquid medium selected from the group of solvents and suspending agents; b) contacting O-desmethylvenlafaxine with a pharmaceutically acceptable acid to form a pharmaceutically acceptable salt of O-desmethylvenlafaxine wherein the pharma-ceutically acceptable acid is selected from the group consisting of maleic acid, citric acid, tartaric acid and L-aspartic acid, optionally filtering the solution; and c) separating the pharmaceutically acceptable salt of 0- desmethylvenlaf axine from the liquid medium to recover the salt, and to pharmaceutical formulations containing these salts.
(FR)La présente invention concerne un procédé de préparation d’un sel de O-desméthylvenlafaxine qui comprend a) la dissolution ou la suspension de O-desméthylvenlafaxine sous la forme de sa base dans un milieu liquide choisi dans le groupe constitué par des solvants et des agents de mise en suspension ; b) la mise en contact de O-desméthylvenlafaxine avec un acide pharmaceutiquement acceptable pour former un sel pharmaceutiquement acceptable de O-desméthylvenlafaxine, l’acide pharmaceutiquement acceptable étant choisi dans le groupe constitué par l’acide maléique, l'acide citrique, l’acide tartrique et l’acide L-aspartique, éventuellement la filtration de la solution ; et c) la séparation du sel pharmaceutiquement acceptable de O-desméthylvenlafaxine du milieu liquide pour récupérer le sel, l’invention concerne en outre des formulations pharmaceutiques contenant ces sels.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)