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1. (WO2009137737) ANTI-BACTERIAL ACTIVITY OF 9-HYDROXY DERIVATIVES OF 6, 11-BICYCLOLIDES
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2009/137737    International Application No.:    PCT/US2009/043225
Publication Date: 12.11.2009 International Filing Date: 08.05.2009
IPC:
A01N 43/04 (2006.01), A61K 31/70 (2006.01)
Applicants: ENANTA PHARMACEUTICALS, INC. [US/US]; 500 Arsenal Street Watertown, MA 02472 (US) (For All Designated States Except US).
IYENGAR, Rajesh [IN/US]; (US) (For US Only).
WANG, Yanchun [CN/US]; (US) (For US Only).
PHAN, Ly, Tam [US/US]; (US) (For US Only).
OR, Yat, Sun [US/US]; (US) (For US Only)
Inventors: IYENGAR, Rajesh; (US).
WANG, Yanchun; (US).
PHAN, Ly, Tam; (US).
OR, Yat, Sun; (US)
Agent: ELMORE, Carolyn, S.; (US)
Priority Data:
61/051,991 09.05.2008 US
Title (EN) ANTI-BACTERIAL ACTIVITY OF 9-HYDROXY DERIVATIVES OF 6, 11-BICYCLOLIDES
(FR) ACTIVITÉ ANTI-BACTÉRIENNE DE DÉRIVÉS 9-HYDROXY DES 6,11-BICYCLOLIDES
Abstract: front page image
(EN)The present invention discloses compounds of formula (I) or pharmaceutically acceptable salts, esters, or prodrugs thereof: which exhibit superior antibacterial properties, particularly against Haemophilus influenzae. The present invention further relates to pharmaceutical compositions comprising the aforementioned compounds for administration to a subject in need of antibiotic treatment. The invention also relates to methods of treating a bacterial infection in a subject by administering a pharmaceutical composition comprising the compounds of the present invention. The invention further includes process by which to make the compounds of the present invention.
(FR)La présente invention concerne des composés de formule (I) ou des promédicaments, esters ou sels de qualité pharmaceutique de ceux-ci, présentant des propriétés antibactériennes supérieures, en particulier contre Haemophilus influenzae. La présente invention concerne, en outre, des compositions pharmaceutiques comprenant les composés susmentionnés, en vue de leur administration à un sujet ayant besoin d'un traitement antibiotique. L'invention concerne également des procédés de traitement d'une infection bactérienne chez un sujet, impliquant l'administration à celui-ci d'une composition pharmaceutique comprenant les composés de la présente invention. L'invention concerne encore un procédé de fabrication des composés de la présente invention.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)