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1. (WO2009137721) LYSOSOMAL TARGETING PEPTIDES AND USES THEREOF
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2009/137721    International Application No.:    PCT/US2009/043207
Publication Date: 12.11.2009 International Filing Date: 07.05.2009
IPC:
C07K 19/00 (2006.01), C07K 14/475 (2006.01)
Applicants: ZYSTOR THERAPEUTICS, INC. [US/US]; 10437 Innovation Drive Suite 100 Milwaukee, WI 53226 (US) (For All Designated States Except US).
LEBOWITZ, Jonathan, H. [US/US]; (US) (For US Only).
MAGA, John [US/US]; (US) (For US Only)
Inventors: LEBOWITZ, Jonathan, H.; (US).
MAGA, John; (US)
Agent: CHEN, Fangli; (US)
Priority Data:
61/144,106 12.01.2009 US
61/051,336 07.05.2008 US
Title (EN) LYSOSOMAL TARGETING PEPTIDES AND USES THEREOF
(FR) PEPTIDES DE CIBLAGE LYSOSOMIAL ET LEURS UTILISATIONS
Abstract: front page image
(EN)The present invention provides further improved compositions and methods for efficient lysosomal targeting based on the GILT technology. Among other things, the present invention provides methods and compositions for targeting lysosomal enzymes to lysosomes using furin-resistant lysosomal targeting peptides. The present invention also provides methods and compositions for targeting lysosomal enzymes to lysosomes using a lysosomal targeting peptide that has reduced or diminished binding affinity for the insulin receptor.
(FR)La présente invention concerne des compositions et procédés encore améliorés de ciblage lysosomial efficace, fondés sur la technologie GILT. La présente invention concerne, entre autres, des procédés et compositions permettant de cibler des enzymes lysosomiales en direction de lysosomes au moyen de peptides de ciblage lysosomial résistants à la furine. La présente invention concerne également des procédés et des compositions permettant de cibler des enzymes lysosomiales en direction de lysosomes au moyen d'un peptide de ciblage lysosomial présentant une affinité de liaison réduite ou minimisée pour le récepteur de l'insuline.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)