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Machine translation
1. (WO2009137717) NOVEL NITROSO COMPOUNDS AS NITROXYL DONORS AND METHODS OF USE THEREOF
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2009/137717    International Application No.:    PCT/US2009/043203
Publication Date: 12.11.2009 International Filing Date: 07.05.2009
IPC:
A61K 31/535 (2006.01)
Applicants: CARDIOXYL PHARMACEUTICALS INC. [US/US]; Exchange East Suite 212 1450 Raleigh Rd. Chapel Hill, NC 27517 (US) (For All Designated States Except US).
FROST, Lisa, Marie [GB/GB]; (GB) (For US Only).
COURTNEY, Stephen, Martin [GB/GB]; (GB) (For US Only).
BROOKFIELD, Frederick, Arthur [GB/GB]; (GB) (For US Only).
KALISH, Vincent, J. [US/US]; (US) (For US Only)
Inventors: FROST, Lisa, Marie; (GB).
COURTNEY, Stephen, Martin; (GB).
BROOKFIELD, Frederick, Arthur; (GB).
KALISH, Vincent, J.; (US)
Agent: ARNOLD & PORTER LLP; (US)
Priority Data:
61/051,287 07.05.2008 US
Title (EN) NOVEL NITROSO COMPOUNDS AS NITROXYL DONORS AND METHODS OF USE THEREOF
(FR) NOUVEAUX COMPOSÉS NITROSÉS EN TANT QUE DONNEURS DE NITROXYLE ET LEURS PROCÉDÉS D’UTILISATION
Abstract: front page image
(EN)The invention relates to nitroso derivatives including carboxylic acid and phosphoric acid esters of hydroxy nitroso compounds that donate nitroxyl (HNO) under physiological conditions. The compounds and compositions of the invention are useful in treating and/or preventing the onset and/or development of diseases or conditions that are responsive to nitroxyl therapy, including heart failure, ischemia/reperfusion injury and cancer.
(FR)La présente invention concerne des dérivés nitroso y compris des esters d’acide carboxylique et d’acide phosphorique de composés hydroxy-nitrosés qui donnent des nitroxyles (HNO) dans des conditions physiologiques. Les composés et les compositions de l’invention sont utiles dans le traitement et/ou la prévention de l’installation et/ou du développement de maladies ou d’affections qui sont réactives à une thérapie par nitroxyle, y compris une insuffisance cardiaque, une lésion d’ischémie/reperfusion et un cancer.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)