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1. (WO2009137338) PYRAZOLE COMPOUNDS AS CCR1 ANTAGONISTS
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2009/137338    International Application No.:    PCT/US2009/042455
Publication Date: 12.11.2009 International Filing Date: 01.05.2009
IPC:
C07D 231/14 (2006.01), C07D 401/12 (2006.01), C07D 405/14 (2006.01), C07D 417/12 (2006.01), A61K 31/415 (2006.01), A61K 31/4155 (2006.01), A61P 29/00 (2006.01)
Applicants: BOEHRINGER INGELHEIM INTERNATIONAL GMBH [DE/DE]; Binger Strasse 173 55216 Ingelheim (DE) (AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BE, BF, BG, BH, BJ, BR, BW, BY, BZ, CA, CF, CG, CH, CI, CM, CN, CO, CR, CU, CY, CZ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, FR, GA, GB, GD, GE, GH, GM, GN, GQ, GR, GT, GW, HN, HR, HU, ID, IE, IL, IN, IS, IT, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LV, LY, MA, MC, MD, ME, MG, MK, ML, MN, MR, MT, MW, MX, MY, MZ, NA, NE, NG, NI, NL, NO, NZ, OM, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SI, SK, SL, SM, SN, ST, SV, SY, SZ, TD, TG, TJ, TM, TN, TR, TT, TZ, UA, UG, UZ, VC, VN, ZA, ZM, ZW only).
BOEHRINGER INGELHEIM PHARMA GMBH & CO. KG [DE/DE]; Binger Strasse 173 55216 Ingelheim (DE) (DE only).
COOK, Brian, Nicholas [US/US]; (US) (For US Only).
HARCKEN, Christian [DE/US]; (US) (For US Only).
LEE, Thomas, Wai-ho [US/US]; (US) (For US Only).
LIU, Pingrong [CN/US]; (US) (For US Only).
MAO, Can [CN/US]; (US) (For US Only).
LORD, John [US/US]; (US) (For US Only).
MAO, Wang [CN/US]; (US) (For US Only).
RAUDENBUSH, Brian, Christopher [US/US]; (US) (For US Only).
RAZAVI, Hossein [US/US]; (US) (For US Only).
SARKO, Christopher, Ronald [US/US]; (US) (For US Only).
SWINAMER, Alan, David [CA/US]; (US) (For US Only)
Inventors: COOK, Brian, Nicholas; (US).
HARCKEN, Christian; (US).
LEE, Thomas, Wai-ho; (US).
LIU, Pingrong; (US).
MAO, Can; (US).
LORD, John; (US).
MAO, Wang; (US).
RAUDENBUSH, Brian, Christopher; (US).
RAZAVI, Hossein; (US).
SARKO, Christopher, Ronald; (US).
SWINAMER, Alan, David; (US)
Agent: MORRIS, Michael, P.; (US)
Priority Data:
61/050,693 06.05.2008 US
Title (EN) PYRAZOLE COMPOUNDS AS CCR1 ANTAGONISTS
(FR) COMPOSÉS DE PYRAZOLE COMME ANTAGONISTES DE CCR1
Abstract: front page image
(EN)Disclosed are compounds of the formula I which block the interaction of CCR1 and its ligands and are thus useful for treating a variety of diseases and disorders that are mediated or sustained through the activity of CCR1 including autoimmune diseases, such as rheumatoid arthritis and multiple sclerosis. Also disclosed are pharmaceutical compositions comprising these compounds, methods of using these compounds in the treatment of various diseases and disorders, processes for preparing these compounds and intermediates useful in these processes.
(FR)La présente invention concerne des composés de formule I qui bloquent l’interaction de CCR1 et de ses ligands et qui sont donc utiles pour le traitement d’une variété de maladies et pathologies qui sont médiées ou soutenues par l’activité de CCR1 parmi lesquelles les maladies auto-immunes, telles que la polyarthrite rhumatoïde et la sclérose en plaques. L’invention concerne également des compositions pharmaceutiques comprenant ces composés, des procédés d’utilisation de ces composés dans le traitement de diverses maladies et pathologies, des procédés de préparation de ces composés et des intermédiaires utiles dans ces procédés.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)