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Machine translation
1. (WO2009137254) MODIFIED FACTOR IX POLYPEPTIDES AND USES THEREOF
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2009/137254    International Application No.:    PCT/US2009/040813
Publication Date: 12.11.2009 International Filing Date: 16.04.2009
IPC:
C07K 14/745 (2006.01)
Applicants: BAYER HEALTHCARE LLC [US/US]; Law and Patents 800 Dwight Way Berkeley, CA 94710 (US) (For All Designated States Except US).
BAYER SCHERING PHARMA AKTIENGESELLSCHAFT [DE/DE]; Mullerstrasse 178 13353 Berlin (DE) (For All Designated States Except US).
BROOKS, Alan [GB/US]; (US) (For US Only).
MURPHY, John, E. [US/US]; (US) (For US Only).
SETO, Marian [US/US]; (US) (For US Only).
JIANG, Xiaoqiao [US/US]; (US) (For US Only).
PATEL, Chandra [US/US]; (US) (For US Only).
GRITZAN, Uwe [DE/DE]; (DE) (For US Only).
KIRCHNER, Kornelia [DE/DE]; (DE) (For US Only).
HAUPTS, Ulrich [DE/DE]; (DE) (For US Only)
Inventors: BROOKS, Alan; (US).
MURPHY, John, E.; (US).
SETO, Marian; (US).
JIANG, Xiaoqiao; (US).
PATEL, Chandra; (US).
GRITZAN, Uwe; (DE).
KIRCHNER, Kornelia; (DE).
HAUPTS, Ulrich; (DE)
Agent: PELLEGRINO, Susan, M.; Bayer HealthCare LLC Law and Patents 800 Dwight Way Berkeley, CA 94710 (US)
Priority Data:
61/124,567 16.04.2008 US
61/045,961 17.04.2008 US
Title (EN) MODIFIED FACTOR IX POLYPEPTIDES AND USES THEREOF
(FR) POLYPEPTIDES MODIFIÉS DE FACTEUR IX ET LEURS UTILISATIONS
Abstract: front page image
(EN)Disclosed are modified Factor IX polypeptides such as Factor IX polypeptides with one or more introduced glycosylation sites. The modified Factor IX polypeptides may exhibit increased in vitro or in vivo stability such as a longer plasma half-life. Also, methods are disclosed of making modified Factor IX polypeptides, and methods of using modified Factor IX polypeptides, for example, to treat patients afflicted with hemophilia B.
(FR)La présente invention concerne des polypeptides modifiés de facteur IX tels que des polypeptides de facteur IX avec un ou des sites de glycosylation introduits. Les polypeptides modifiés de facteur IX peuvent présenter une stabilité accrue in vitro ou in vivo telle qu’une demi-vie plasmatique plus longue. L’invention concerne également des procédés de fabrication de polypeptides modifiés de facteur IX, et des procédés d’utilisation de polypeptides modifiés de facteur IX, par exemple, pour traiter des patients atteints de l’hémophilie B.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)