WIPO logo
Mobile | Deutsch | Español | Français | 日本語 | 한국어 | Português | Русский | 中文 | العربية |
PATENTSCOPE

Search International and National Patent Collections
World Intellectual Property Organization
Search
 
Browse
 
Translate
 
Options
 
News
 
Login
 
Help
 
Machine translation
1. (WO2009137084) PROCESSES FOR PREPARATION OF TAXANES AND INTERMEDIATES THEREOF
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2009/137084    International Application No.:    PCT/US2009/002851
Publication Date: 12.11.2009 International Filing Date: 06.05.2009
IPC:
C07D 305/14 (2006.01)
Applicants: IVAX RESEARCH, LLC [CZ/CZ]; Ostravska 29 747 70 Opava 9 (CZ) (AE, AG, AL, AM, AO, AT, AU, AZ, BA, BE, BF, BG, BH, BJ, BR, BW, BY, BZ, CA, CF, CG, CH, CI, CM, CN, CO, CR, CU, CY, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, FR, GA, GB, GD, GE, GH, GM, GN, GQ, GR, GT, GW, HN, HR, HU, ID, IE, IL, IN, IS, IT, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LV, LY, MA, MC, MD, ME, MG, MK, ML, MN, MR, MT, MW, MX, MY, MZ, NA, NE, NG, NI, NL, NO, NZ, OM, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SI, SK, SL, SM, SN, ST, SV, SY, SZ, TD, TG, TJ, TM, TN, TR, TT, TZ, UA, UG, UZ, VC, VN, ZA, ZM, ZW only).
TEVA PHARMACEUTICALS USA, INC. [US/US]; 1090 Horsham Road P.o. Box 1090 North Wales, PA 19454-1090 (US) (BB only).
CVAK, Ladislav [CZ/CZ]; (CZ) (For US Only).
VALIK, Martin [CZ/CZ]; (CZ) (For US Only).
HOLAS, Tomas [CZ/CZ]; (CZ) (For US Only).
MALECEK, Jiri [CZ/CZ]; (CZ) (For US Only)
Inventors: CVAK, Ladislav; (CZ).
VALIK, Martin; (CZ).
HOLAS, Tomas; (CZ).
MALECEK, Jiri; (CZ)
Agent: BIRDE, Patrick, J.; (US)
Priority Data:
61/132,208 16.06.2008 US
61/126,861 07.05.2008 US
61/131,838 11.06.2008 US
Title (EN) PROCESSES FOR PREPARATION OF TAXANES AND INTERMEDIATES THEREOF
(FR) PROCESSUS DE PRÉPARATION DES TAXANES ET DE LEURS INTERMÉDIAIRES
Abstract: front page image
(EN)A paclitaxel intermediate of formula 1 : wherein R1 is acetyl, R2 is tert-butyloxycarbonyl (BOC), R3 and R4 are phenyl and R5 is 1- ethoxyethyl, is provided. Also provided are processes for preparing taxane intermediates of formula 1 comprising reacting a compound of formula 2 with a compound of formula 3 wherein, R1, R2 and R5 are independently a hydroxyl protecting group; R3 is phenyl, substituted phenyl, a straight or branched alkyl containing 1 to 12 carbon atoms, alkenyl containing 2 to 12 carbon atoms, cycloalkyl containing 4 to 15 carbon atoms, cycloalkenyl or an R6-O- group in which R6 is: phenyl, substituted phenyl group, a C1-C8 straight or branched alkyl, a C2-C8 straight or branched alkenyl group, a C3-C8 straight or branched alkynyl, a C3-C7 cycloalkyl, C4-C7 cycloalkenyl, a C7-C11 bicycloalkyl substituent, or a saturated or unsaturated nitrogen; and R4 is phenyl or a substituted phenyl group.
(FR)Cette invention concerne un intermédiaire de paclitaxel de formule 1, dans laquelle R1 est acétyle, R2 est tert-butyloxycarbonyle (BOC), R3 et R4 sont phényle et R5 est 1-éthoxyéthyle. L’invention concerne également des processus de préparation d’intermédiaires de taxanes de formule 1 comprenant la mise en réaction d’un composé de formule 2 avec un composé de formule 3, R1, R2 et R5 étant indépendamment un groupe protecteur hydroxyle, R3 étant phényle, phényle substitué, alkyle linéaire ou ramifié contenant de 1 à 12 atomes de carbone, alcényle contenant 2 à 12 atomes de carbone, cycloalkyle contenant 4 à 15 atomes de carbone, cycloalcényle ou un groupe R6-O- où R6 est phényle, groupe à substitution phényle, un alkyle en C1-C8 linéaire ou ramifié, un groupe alcényle en C2-C8 linéaire ou ramifié, un alcynyle en C3-C8 linéaire ou ramifié, un cycloalkyle en C3-C7, un cycloalcényle en C4-C7, un substituant bicycloalkyle en C7-C11 ou un azote saturé ou insaturé, et R4 étant phényle ou un groupe phényle substitué.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)