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1. (WO2009137045) CRYSTAL STRUCTURE OF ALDEHYDE DEHYDROGENASE AND METHODS OF USE THEREOF
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2009/137045    International Application No.:    PCT/US2009/002783
Publication Date: 12.11.2009 International Filing Date: 04.05.2009
IPC:
C12N 9/02 (2006.01), C12N 9/00 (2006.01), G01N 33/48 (2006.01)
Applicants: THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY [US/US]; 1705 El Camino Real Palo Alto, CA 94306-1106 (US) (For All Designated States Except US).
INDIANA UNIVERSITY RESEARCH AND TECHNOLOGY CORPORATION [US/US]; 3082 351 West 10th Street Indianapolis, IN 46202 (US) (For All Designated States Except US).
CHEN, Che-hong [US/US]; (US) (For US Only).
HURLEY, Thomas, D. [US/US]; (US) (For US Only).
MOCHLY-ROSEN, Daria [US/US]; (US) (For US Only)
Inventors: CHEN, Che-hong; (US).
HURLEY, Thomas, D.; (US).
MOCHLY-ROSEN, Daria; (US)
Agent: BORDEN, Paula, A.; Bozicevic, Field & Francis LLP 1900 University Avenue, Suite 200 East Palo Alto, CA 94303 (US)
Priority Data:
61/126,890 07.05.2008 US
Title (EN) CRYSTAL STRUCTURE OF ALDEHYDE DEHYDROGENASE AND METHODS OF USE THEREOF
(FR) STRUCTURE CRISTALLINE D'ALDÉHYDE DÉSHYDROGÉNASE ET PROCÉDÉS D'UTILISATION
Abstract: front page image
(EN)The present disclosure provides a crystal structure of aldehyde dehydrogenase (ALDH) with a modulator of ALDH bound thereto. The present disclosure provides a computer readable medium comprising atomic coordinates for an ALDH polypeptide and a modulator bound to a site within the polypeptide. A method is also provided. In general terms, the method comprises computationally identifying a compound that binds to an ALDH polypeptide, using the atomic coordinates.
(FR)La présente invention concerne une structure cristalline d'aldéhyde déshydrogénase (ALDH) à laquelle est lié un modulateur d'ALDH. La présente invention propose un support lisible par ordinateur comprenant des coordonnées atomiques d'un polypeptide ALDH et d'un modulateur d'ALDH lié à un site au sein du polypeptide. Un procédé est également proposé. En termes généraux, le procédé comprend l'identification par calcul d'un composé qui se lie à un polypeptide ALDH, à l'aide des coordonnées atomiques.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)