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Machine translation
1. (WO2009136903) STABLE OPHTHALMICAL COMPOSITION COMPRISING KETOTIFEN AND NAPHAZOLINE AND METHODS OF MAKING SAME
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2009/136903    International Application No.:    PCT/US2008/057431
Publication Date: 12.11.2009 International Filing Date: 19.03.2008
Chapter 2 Demand Filed:    20.01.2009    
IPC:
A61K 9/08 (2006.01), A61K 31/445 (2006.01)
Applicants: BAUSCH & LOMB INCORPORATED [US/US]; One Bausch & Lomb Place Rochester, NY 14604-2701 (US) (For All Designated States Except US).
BRYANT, Roy, W. [US/US]; (US) (For US Only).
PARIHAR, Ravi [US/US]; (US) (For US Only).
ROWE, Thomas [US/US]; (US) (For US Only).
CABALLA, Susan [US/US]; (US) (For US Only)
Inventors: BRYANT, Roy, W.; (US).
PARIHAR, Ravi; (US).
ROWE, Thomas; (US).
CABALLA, Susan; (US)
Agent: VO, Toan, P.; (US)
Priority Data:
11/689,091 21.03.2007 US
Title (EN) STABLE OPHTHALMICAL COMPOSITION COMPRISING KETOTIFEN AND NAPHAZOLINE AND METHODS OF MAKING SAME
(FR) COMPOSITION OPHTALMIQUE STABLE COMPRENANT DU KÉTOTIFÈNE ET DE LA NAPHAZOLINE ET SES PROCÉDÉS DE FABRICATION
Abstract: front page image
(EN)Stable compositions comprising ketotifen or a ketotifen salt and methods of preparing such compositions are provided. The pH of the compositions remains at less than about 5 during storage. The methods comprise preparing pharmaceutical compositions comprising ketotifen or a ketotifen salt, and adjusting their pH to less than 5, thus slowing the changes of the active ingredients.
(FR)La présente invention concerne des compositions stables comprenant du kétotifène ou un sel de kétotifène et des procédés de préparation de telles compositions. Le pH des compositions reste inférieur à environ 5 pendant le stockage. Les procédés comprennent la préparation de compositions pharmaceutiques comprenant du kétotifène ou un sel de kétotifène, et l'ajustement de leur pH à une valeur inférieure à 5, ce qui freine les changements des ingrédients actifs.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, SV, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MT, NL, NO, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)