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1. (WO2009136599) NON-COVALENT CROSSLINKING AGENT FOR COLLAGEN
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2009/136599    International Application No.:    PCT/JP2009/058554
Publication Date: 12.11.2009 International Filing Date: 01.05.2009
Chapter 2 Demand Filed:    28.12.2009    
IPC:
A61K 38/00 (2006.01), A61P 27/02 (2006.01), A61L 26/00 (2006.01)
Applicants: OSAKA UNIVERSITY [JP/JP]; 1-1, Yamadaoka, Suita-shi, Osaka 5650871 (JP) (For All Designated States Except US).
TOHOKU UNIVERSITY [JP/JP]; 1-1, Katahira 2-chome, Aoba-ku, Sendai-shi, Miyagi 9808577 (JP) (For All Designated States Except US).
AKASHI, Mitsuru [JP/JP]; (JP) (For US Only).
NISHIDA, Kohji [JP/JP]; (JP) (For US Only).
MATSUSAKI, Michiya [JP/JP]; (JP) (For US Only).
KUBOTA, Akira [JP/JP]; (JP) (For US Only).
WAKU, Tomonori [JP/JP]; (JP) (For US Only)
Inventors: AKASHI, Mitsuru; (JP).
NISHIDA, Kohji; (JP).
MATSUSAKI, Michiya; (JP).
KUBOTA, Akira; (JP).
WAKU, Tomonori; (JP)
Agent: TANAKA, Mitsuo; AOYAMA & PARTNERS, IMP Building, 3-7, Shiromi 1-chome, Chuo-ku, Osaka-shi, Osaka 5400001 (JP)
Priority Data:
2008-121073 07.05.2008 JP
Title (EN) NON-COVALENT CROSSLINKING AGENT FOR COLLAGEN
(FR) AGENT DE RÉTICULATION NON COVALENTE POUR LE COLLAGÈNE
(JA) 非共有結合型コラーゲン架橋剤
Abstract: front page image
(EN)Disclosed is a cross-linking agent for collagen, which is free of problems such as the detrimental effect of the irradiation with ultraviolet ray or the toxicity of residual monomers or unreacted functional groups, and has excellent biocompatibility. Specifically disclosed is a non-covalent cross-linking agent for collagen (particularly for a fibrous protein collagen), which comprises: a spacer which comprises a polyhydric alcohol having two or more OH groups at the terminal; and an arm which comprises a collagen peptide composed of an amino acid triplet repeat and is bound to the spacer via the OH groups.
(FR)La présente invention concerne un agent de réticulation pour le collagène qui ne présente pas de problèmes tels que l’effet nocif d’une irradiation par les rayons ultraviolets ou la toxicité des monomères résiduels ou des groupes fonctionnels qui n’ont pas réagi, et qui affiche une excellente biocompatibilité. L’invention concerne spécifiquement un agent de réticulation non covalente pour le collagène (particulièrement le collagène protéine fibreuse) qui comprend : un espaceur qui comprend un polyol ayant deux groupes OH ou plus à l’extrémité ; et un bras qui comprend un peptide du collagène composé de la répétition d’un triplet d’acides aminés et qui est lié à l’espaceur par l’intermédiaire des groupes OH.
(JA) 紫外線照射の弊害、残存モノマーや未反応官能基による毒性等の問題のない生体適合性に優れたコラーゲン架橋剤を提供することを目的とする。 末端に2個以上のOH基を有する多価アルコールからなるスペーサーおよび、該OH基を介して、3つのアミノ酸の繰り返しで構成されるコラーゲンペプチドからなるアームがスペーサーに結合されている、(繊維状タンパク質コラーゲンの)非共有結合型コラーゲン架橋剤を提供する。
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: Japanese (JA)
Filing Language: Japanese (JA)