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Machine translation
1. (WO2009136382) ANTIBODIES TO RECEPTOR OF ADVANCED GLYCATION END PRODUCTS (RAGE) AND USES THEREOF
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2009/136382    International Application No.:    PCT/IB2009/051915
Publication Date: 12.11.2009 International Filing Date: 08.05.2009
IPC:
C12N 15/12 (2006.01), C12N 5/00 (2006.01), C12N 7/00 (2006.01)
Applicants: ABBOTT GMBH & CO. KG [DE/DE]; Max-Planck-Ring 2 65205 Wiesbaden (DE) (For All Designated States Except US).
Abbott Laboratories [US/US]; 100 Abbott Park Road Abbott Park, Illinois 60064 (US) (For All Designated States Except US).
GU, Jijie [US/US]; (US) (For US Only).
HSIEH, Chung-Ming [US/US]; (US) (For US Only).
WU, Zhen [CN/US]; (US) (For US Only).
DIGIAMMARINO, Enrico L. [US/US]; (US) (For US Only).
LUO, Feng [CN/US]; (US) (For US Only).
FOX, Gerard B. [US/US]; (US) (For US Only).
HARLAN, John E. [US/US]; (US) (For US Only).
SCHMIDT, Martin [DE/DE]; (DE) (For US Only).
LOEBBERT, Ralf [DE/DE]; (DE) (For US Only).
MUELLER, Reinhold [DE/DE]; (DE) (For US Only).
EBERT, Ulrich [DE/DE]; (DE) (For US Only).
NIMMRICH, Volker [DE/DE]; (DE) (For US Only)
Inventors: GU, Jijie; (US).
HSIEH, Chung-Ming; (US).
WU, Zhen; (US).
DIGIAMMARINO, Enrico L.; (US).
LUO, Feng; (US).
FOX, Gerard B.; (US).
HARLAN, John E.; (US).
SCHMIDT, Martin; (DE).
LOEBBERT, Ralf; (DE).
MUELLER, Reinhold; (DE).
EBERT, Ulrich; (DE).
NIMMRICH, Volker; (DE)
Agent: Patentanwälte Reitstötter Kinzebach; Sternwartstr. 4 81679 München (DE)
Priority Data:
61/051,863 09.05.2008 US
61/093,416 01.09.2008 US
Title (EN) ANTIBODIES TO RECEPTOR OF ADVANCED GLYCATION END PRODUCTS (RAGE) AND USES THEREOF
(FR) ANTICORPS CONTRE LE RÉCEPTEUR DES PRODUITS TERMINAUX DE GLYCATION AVANCÉE (RAGE) ET LEURS UTILISATIONS
Abstract: front page image
(EN)The present application relates to isolated proteins, particularly monoclonal antibodies, in particular CDR-grafted, humanized antibodies which bind to RAGE protein. Specifically, these antibodies have the ability to inhibit the binding of RAGE to its various ligands. The antibodies or portions thereof of described in the present application are useful for treating a disease or disorder characterized by or induced by pathophysiological ligands of RAGE, for example missfolded proteins like amyloid β and advanced glycation-end-products.
(FR)La présente invention concerne des protéines isolées, notamment des anticorps monoclonaux, particulièrement des anticorps humanisés CDR-greffés, qui se lient à une protéine RAGE. Spécifiquement, ces anticorps présentent la capacité d’inhiber la liaison d’un RAGE à ses différents ligands. Les anticorps ou des parties de ceux-ci décrits dans la présente invention sont utiles pour le traitement d’une maladie ou d’un trouble caractérisé par ou induit par des ligands physiopathologiques des RAGE, par exemple des protéines mal pliées telles que l’amyloïde β et les produits terminaux de glycation avancée.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)